ArticleProceedings of the National Academy of Sciences of the United States of America1996
Taste receptor-like cells in the rat gut identified by expression of alpha-gustducin.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 158 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
158 citing papers in PubMed, 394 citations in OpenAlex.
- Trial
- A Single 48 mg Sucralose Sip Unbalances Monocyte Subpopulations and Stimulates Insulin Secretion in Healthy Young Adults.Journal of immunology research · 2019Trial
- Disordered control of intestinal sweet taste receptor expression and glucose absorption in type 2 diabetes.Diabetes · 2013Trial
- Article
- Bitter Compounds as Multifunctional Agents against Diabetes-associated Cognitive Dysfunction: Bridging Metabolic Regulation and Neuroprotection.Mini reviews in medicinal chemistry · 2026Review
- Acute tuft cell ablation in mice induces malabsorption and alterations in secretory and immune cell lineages in the small intestine.Physiological reports · 2025Article
- Bitter taste receptors.Chemical senses · 2025Review
- Generation and functional characterization of tuft cells in non-human primate pancreatic ducts through organoid culture systems.Frontiers in cell and developmental biology · 2025Article
- Bitter taste receptors as sensors of gut luminal contents.Nature reviews. Gastroenterology & hepatology · 2025Review
- Acetylcholine from tuft cells promotes M2 macrophages polarization in Hirschsprung-associated enterocolitis.Frontiers in immunology · 2025Article
- Physiological activation of human and mouse bitter taste receptors by bile acids.Communications biology · 2023Article
- A Bitter Taste Receptor as a Novel Molecular Target on Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Initiation of type 2 immunity at barrier surfaces.Mucosal immunology · 2023Review
- Tuft cells utilize taste signaling molecules to respond to the pathobiont microbeFrontiers in immunology · 2023Article
- Identification of Differentiated Intestinal Epithelial Cells Using Immunostaining and Fluorescence Microscopy.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Possible connection between intestinal tuft cells, ILC2s and obesity.Frontiers in immunology · 2023Review
- Tuft Cells Are Present in Submandibular Glands Across Species.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2022Article
- Factors Regulating or Regulated by Myogenic Regulatory Factors in Skeletal Muscle Stem Cells.Cells · 2022Review
- Tuft cells are key mediators of interkingdom interactions at mucosal barrier surfaces.PLoS pathogens · 2022Review
- Tuft Cells and Their Role in Intestinal Diseases.Frontiers in immunology · 2022Review
98 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The alpha-subunit of the trimeric G-protein complex specific for taste receptor cells of the tongue, alpha-gustducin, is described here to be also expressed in the stomach and intestine. The alpha-gustducin-containing cells were identified as brush cells that are scattered throughout the surface epithelium of the gut and share structural features of taste receptor cells of the tongue. These findings provide clues to the long-sought molecular and cellular basis for chemoreception in the gut.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.