ArticleProceedings of the National Academy of Sciences of the United States of America1996
Development of Valpha4+ NK T cells in the early stages of embryogenesis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Invariant NKT Cells and Control of the Thymus Medulla.Journal of immunology (Baltimore, Md. : 1950) · 2018Review
- Discovery of NKT cells and development of NKT cell-targeted anti-tumor immunotherapy.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2015Review
- Orchestration of invariant natural killer T cell development by E and Id proteins.Critical reviews in immunology · 2015Review
- Combined deletion of Id2 and Id3 genes reveals multiple roles for E proteins in invariant NKT cell development and expansion.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Transcriptional control of invariant NKT cell development.Immunological reviews · 2010Article
- Identification of CD4(-)CD8(-) double-negative natural killer T cell precursors in the thymus.PloS one · 2008Article
- Th1 or Th2 balance regulated by interaction between dendritic cells and NKT cells.Immunologic research · 2007Review
- Characterization of the early stages of thymic NKT cell development.The Journal of experimental medicine · 2005Article
- Innate self recognition by an invariant, rearranged T-cell receptor and its immune consequences.Immunology · 2003Review
- A natural killer T (NKT) cell developmental pathway iInvolving a thymus-dependent NK1.1(-)CD4(+) CD1d-dependent precursor stage.The Journal of experimental medicine · 2002Article
- Disrupting the IL-4 gene rescues mice homozygous for the tight-skin mutation from embryonic death and diminishes TGF-beta production by fibroblasts.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Requirement for natural killer T (NKT) cells in the induction of allograft tolerance.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Thymus-independent expansion of T lymphocytes in children after allogeneic bone marrow transplantation.Bone marrow transplantation · 2000Article
- Augmentation of Valpha14 NKT cell-mediated cytotoxicity by interleukin 4 in an autocrine mechanism resulting in the development of concanavalin A-induced hepatitis.The Journal of experimental medicine · 2000Article
- Inhibition of T helper cell type 2 cell differentiation and immunoglobulin E response by ligand-activated Valpha14 natural killer T cells.The Journal of experimental medicine · 1999Article
- Induction of differentiation of pre-NKT cells to mature Valpha14 NKT cells by granulocyte/macrophage colony-stimulating factor.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated Valpha14 NKT cells.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Distinct roles for signals relayed through the common cytokine receptor gamma chain and interleukin 7 receptor alpha chain in natural T cell development.The Journal of experimental medicine · 1997Article
- Essential requirement of an invariant V alpha 14 T cell antigen receptor expression in the development of natural killer T cells.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The majority of T lymphocytes start to develop at around day 15 of gestation (d15)-d17 in the thymus and comprise the peripheral repertoire characterized by the expression of polymorphic T-cell antigen receptors (TCRs). Contrary to these conventional T cells, a subset of T cells, called natural killer (NK) T cells (most of them expressing an invariant TCR encoded by the Valpha14Jalpha281 gene with a 1-nt N-region), preferentially differentiates extrathymically and dominates the peripheral T-cell population at a high frequency (5% in splenic T cells and 40% in bone marrow T cells). Here, we investigated the development of NK T cells and found that the invariant Valpha14+ TCR transcripts and the circular DNA created by Valpha14 and Jalpha281 gene rearrangements can be detected in the embryo body at d9.5 of gestation and in the yolk sac and the fetal liver at d11.5-d13.5 of gestation, but not in the thymus, whereas T cells with Valpha1+ TCR expression, a major population in the thymus, were not observed at these early stages of gestation. Fluorescence-activated cell sorter analysis also demonstrated that there exist CD3+ alpha beta+ T cells, almost all of which are Valpha14/Vbeta8+ NK+ T cells, during early embryogenesis. To our knowledge, this demonstrates for the first time that a T lymphocyte subset develops in extrathymic tissues during the early stages of embryogenesis.
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