ArticleProceedings of the National Academy of Sciences of the United States of America1996
Microsatellite spreading in the human genome: evolutionary mechanisms and structural implications.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 170 citations in OpenAlex.
- Review
- Article
- STRs: Ancient Architectures of the Genome beyond the Sequence.Journal of molecular neuroscience : MN · 2021Review
- Review
- Article
- Evolution of the Proto Sex-Chromosome inInternational journal of molecular sciences · 2019Article
- Review
- Genome-wide mapping and characterization of microsatellites in the swamp eel genome.Scientific reports · 2017Article
- A comparative genomics approach revealed evolutionary dynamics of microsatellite imperfection and conservation in genusHereditas · 2017Article
- High-throughput sequencing and graph-based cluster analysis facilitate microsatellite development from a highly complex genome.Ecology and evolution · 2016Article
- Discovery of a new repeat family in the Callithrix jacchus genome.Genome research · 2016Article
- Transposable elements and G-quadruplexes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2015Review
- Chromosomal distribution of microsatellite repeats in Amazon cichlids genome (Pisces, Cichlidae).Comparative cytogenetics · 2015Article
- Homopolymer tract organization in the human malarial parasite Plasmodium falciparum and related Apicomplexan parasites.BMC genomics · 2014Article
- Article
- Transposable elements and their potential role in complex lung disorder.Respiratory research · 2013Review
- Developing molecular tools and insights into the Penstemon genome using genomic reduction and next-generation sequencing.BMC genetics · 2013Article
- Non-LTR retrotransposons and microsatellites: Partners in genomic variation.Mobile genetic elements · 2013Review
- Overlapping genes of Aedes aegypti: evolutionary implications from comparison with orthologs of Anopheles gambiae and other insects.BMC evolutionary biology · 2013Article
- LINE-1-derived poly(A) microsatellites undergo rapid shortening and create somatic and germline mosaicism in mice.Molecular biology and evolution · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microsatellites are tandem repeat sequences abundant in the genomes of higher eukaryotes and hitherto considered as "junk DNA." Analysis of a human genome representative data base (2.84 Mb) reveals a distinct juxtaposition of A-rich microsatellites and retroposons and suggests their coevolution. The analysis implies that most microsatellites were generated by a 3'-extension of retrotranscripts, similar to mRNA polyadenylylation, and that they serve in turn as "retroposition navigators," directing the retroposons via homology-driven integration into defined sites. Thus, they became instrumental in the preservation and extension of primordial genomic patterns. A role is assigned to these reiterating A-rich loci in the higher-order organization of the chromatin. The disease-associated triplet repeats are mostly found in coding regions and do not show an association with retroposons, constituting a unique set within the family of microsatellite sequences.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.