ArticleProceedings of the National Academy of Sciences of the United States of America1996
31P NMR magnetization transfer study of the control of ATP turnover in Saccharomyces cerevisiae.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 35 citations in OpenAlex.
- Maintenance-energy requirements and robustness of Saccharomyces cerevisiae at aerobic near-zero specific growth rates.Microbial cell factories · 2016Article
- 31P magnetization transfer measurements of Pi→ATP flux in exercising human muscle.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Functional roles of nucleosome stability and dynamics.Briefings in functional genomics · 2015Review
- Monitoring ATP hydrolysis and ATPase inhibitor screening using (1)H NMR.Chemical communications (Cambridge, England) · 2014Article
- Constant growth rate can be supported by decreasing energy flux and increasing aerobic glycolysis.Cell reports · 2014Article
- High-intensity interval training increases in vivo oxidative capacity with no effect on P(i)→ATP rate in resting human muscle.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- ³¹P-magnetization transfer magnetic resonance spectroscopy measurements of in vivo metabolism.Diabetes · 2012Review
- Mechanism of Mss116 ATPase reveals functional diversity of DEAD-Box proteins.Journal of molecular biology · 2011Article
- Decrease in oxidative phosphorylation yield in presence of butyrate in perfused liver isolated from fed rats.BMC physiology · 2007Article
- The basal proton conductance of mitochondria depends on adenine nucleotide translocase content.The Biochemical journal · 2005Article
- Does any yeast mitochondrial carrier have a native uncoupling protein function?Journal of bioenergetics and biomembranes · 2002Article
- Glucose metabolism in gcr mutants of Saccharomyces cerevisiae.Journal of bacteriology · 1999Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
31P NMR magnetization transfer measurements have been used to measure the steady state flux between Pi and ATP in yeast cells genetically modified to overexpress an adenine nucleotide translocase isoform. An increase in Pi -> ATP flux and apparent ratio of moles of ATP synthesized/atoms of oxygen consumed (P:O ratio), when these cells were incubated with glucose, demonstrated that the reactions catalyzed by the translocase and F1F0 ATP synthase were readily reversible in vivo. However, when the same cells were incubated with ethanol alone, translocase overexpression had no effect on the measured Pi -> ATP flux or apparent P:O ratio, suggesting that the synthase was now operating irreversibly. This change was accompanied by an increase in the intracellular ADP concentration. These observations are consistent with a model proposed for the kinetic control of mitochondrial ATP synthesis, which was based on isotope exchange measurements with isolated mammalian mitochondria [LaNoue, K. F., Jeffries, F. M. H. & Radda, G. K. (1986) Biochemistry 25, 7667-7675].
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