ArticleProceedings of the National Academy of Sciences of the United States of America1996
Positive genetic feedback governs cAMP spiral wave formation in Dictyostelium.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Bridging single cells to organs: Mesoscale modules as fundamental units of tissue function.Cell · 2025Review
- Excitable dynamics driven by mechanical feedback in biological tissues.Communications physics · 2024Article
- Multi-scale organization in communicating active matter.Nature communications · 2022Article
- Exploring rare cellular activity in more than one million cells by a transscale scope.Scientific reports · 2021Article
- Spontaneous center formation in Dictyostelium discoideum.Scientific reports · 2019Article
- A critical-like collective state leads to long-range cell communication in Dictyostelium discoideum aggregation.PLoS biology · 2017Article
- Excitable waves and direction-sensing in Dictyostelium discoideum: steps towards a chemotaxis model.Physical biology · 2016Article
- Regulation of Spatiotemporal Patterns by Biological Variability: General Principles and Applications to Dictyostelium discoideum.PLoS computational biology · 2015Review
- Article
- From intracellular signaling to population oscillations: bridging size- and time-scales in collective behavior.Molecular systems biology · 2015Article
- Learning physics of living systems from Dictyostelium.Physical biology · 2014Article
- Noise in biology.Reports on progress in physics. Physical Society (Great Britain) · 2014Review
- Predictability of spatio-temporal patterns in a lattice of coupled FitzHugh-Nagumo oscillators.Journal of the Royal Society, Interface · 2013Article
- Robustness of self-organizing chemoattractant field arising from precise pulse induction of its breakdown enzyme: a single-cell level analysis of PDE expression in Dictyostelium.Biophysical journal · 2013Article
- Modeling and measuring signal relay in noisy directed migration of cell groups.PLoS computational biology · 2013Article
- Approaching the molecular origins of collective dynamics in oscillating cell populations.Current opinion in genetics & development · 2010Review
- Streaming instability in growing cell populations.Physical review letters · 2010Article
- The group migration of Dictyostelium cells is regulated by extracellular chemoattractant degradation.Molecular biology of the cell · 2009Article
- Predicting the distribution of spiral waves from cell properties in a developmental-path model of Dictyostelium pattern formation.PLoS computational biology · 2009Article
- Reconstruction of cellular variability from spatiotemporal patterns of Dictyostelium discoideum.Nonlinear biomedical physics · 2007Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aggregation stage of the life cycle of Dictyostelium discoideum is governed by the chemotactic response of individual amoebae to excitable waves of cAMP. We modeled this process through a recently introduced hybrid automata-continuum scheme and used computer simulation to unravel the role of specific components of this complex developmental process. Our results indicated an essential role for positive feedback between the cAMP signaling and the expression of the genes encoding the signal transduction and response machinery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.