ArticleProceedings of the National Academy of Sciences of the United States of America1996
Dynamic methylation adjustment and counting as part of imprinting mechanisms.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- FTDC1/2, oocyte-specific cofactors of DNMT1 required for epigenetic regulation and embryonic development.Cell death and differentiation · 2025Article
- Review
- Loss of Monoallelic Expression ofFrontiers in genetics · 2022Article
- DNA methylation predicts age and provides insight into exceptional longevity of bats.Nature communications · 2021Article
- Locus-specific analysis of DNA methylation patterns in cloned and in vitro fertilized porcine embryos.The Journal of reproduction and development · 2020Article
- Effects of DNMT1 and HDAC inhibitors on gene-specific methylation reprogramming during porcine somatic cell nuclear transfer.PloS one · 2013Article
- Analysis of imprinted gene expression in normal fertilized and uniparental preimplantation porcine embryos.PloS one · 2011Article
- The relationship of DNA methylation with age, gender and genotype in twins and healthy controls.PloS one · 2009Article
- Interferon regulatory factors IRF5 and IRF7 inhibit growth and induce senescence in immortal Li-Fraumeni fibroblasts.Molecular cancer research : MCR · 2008Article
- Adult mice cloned from migrating primordial germ cells.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- High concentrations of long interspersed nuclear element sequence distinguish monoallelically expressed genes.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Gatm, a creatine synthesis enzyme, is imprinted in mouse placenta.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Domain regulation of imprinting cluster in Kip2/Lit1 subdomain on mouse chromosome 7F4/F5: large-scale DNA methylation analysis reveals that DMR-Lit1 is a putative imprinting control region.Genome research · 2002Article
- The imprinting mechanism of the Prader-Willi/Angelman regional control center.The EMBO journal · 2002Article
- Genetic conflicts in genomic imprinting.Proceedings. Biological sciences · 1998Article
- Regulation of X-chromosome inactivation in development in mice and humans.Microbiology and molecular biology reviews : MMBR · 1998Review
- Clonal heterogeneity at allelic methylation sites diagnostic for Prader-Willi and Angelman syndromes.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Structure of the imprinted mouse Snrpn gene and establishment of its parental-specific methylation pattern.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Loss of the maternal H19 gene induces changes in Igf2 methylation in both cis and trans.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- A 5' 2-kilobase-pair region of the imprinted mouse H19 gene exhibits exclusive paternal methylation throughout development.Molecular and cellular biology · 1997Article
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6 authors.
Funding
Abstract
Monoallelic expression in diploid mammalian cells appears to be a widespread phenomenon, with the most studied examples being X-chromosome inactivation in eutherian female cells and genomic imprinting in the mouse and human. Silencing and methylation of certain sites on one of the two alleles in somatic cells is specific with respect to parental source for imprinted genes and random for X-linked genes. We report here evidence indicating that: (i) differential methylation patterns of imprinted genes are not simply copied from the gametes, but rather established gradually after fertilization; (ii) very similar methylation patterns are observed for diploid, tetraploid, parthenogenic, and androgenic preimplantation mouse embryos, as well as parthenogenic and androgenic mouse embryonic stem cells; (iii) haploid parthenogenic embryos do not show methylation adjustment as seen in diploid or tetraploid embryos, but rather retain the maternal pattern. These observations suggest that differential methylation in imprinted genes is achieved by a dynamic process that senses gene dosage and adjusts methylation similar to X-chromosome inactivation.
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