ArticleProceedings of the National Academy of Sciences of the United States of America1996
Cystic fibrosis gene encodes a cAMP-dependent chloride channel in heart.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 65 citations in OpenAlex.
- Mitochondrial dysfunction is a key link involved in the pathogenesis of sick sinus syndrome: a review.Frontiers in cardiovascular medicine · 2024Review
- Nickel inhibits β-1 adrenoceptor mediated activation of cardiac CFTR chloride channels.Biochemical and biophysical research communications · 2013Article
- Arrhythmia and sudden death associated with elevated cardiac chloride channel activity.Journal of cellular and molecular medicine · 2011Article
- Endothelial and smooth muscle cell ion channels in pulmonary vasoconstriction and vascular remodeling.Comprehensive Physiology · 2011Review
- Cardiomyocytes with disrupted CFTR function require CaMKII and Ca(2+)-activated Cl(-) channel activity to maintain contraction rate.The Journal of physiology · 2010Article
- Lack of CFTR in skeletal muscle predisposes to muscle wasting and diaphragm muscle pump failure in cystic fibrosis mice.PLoS genetics · 2009Article
- The PEST sequence does not contribute to the stability of the cystic fibrosis transmembrane conductance regulator.BMC biochemistry · 2002Article
- Intracellular cyclic AMP inhibits native and recombinant volume-regulated chloride channels from mammalian heart.The Journal of physiology · 2000Article
- Purinoceptor-coupled Cl- channels in mouse heart: a novel, alternative pathway for CFTR regulation.The Journal of physiology · 1999Article
- Regulation of recombinant cardiac cystic fibrosis transmembrane conductance regulator chloride channels by protein kinase C.Biophysical journal · 1999Article
- Regulation of chloride secretion across porcine endometrial epithelial cells by prostaglandin E2.The Journal of physiology · 1998Article
- Genomic DNA sequence of Rhesus (M. mulatta) cystic fibrosis (CFTR) gene.Mammalian genome : official journal of the International Mammalian Genome Society · 1998Article
- Swelling-induced Cl- current in guinea-pig atrial myocytes: inhibition by glibenclamide.The Journal of physiology · 1997Article
- Regulatory volume decrease of cardiac myocytes induced by beta-adrenergic activation of the Cl- channel in guinea pig.The Journal of general physiology · 1997Article
- Functional activity of the CFTR Cl- channel in human myocardium.Heart and vessels · 1997Article
- Human epithelial cystic fibrosis transmembrane conductance regulator without exon 5 maintains partial chloride channel function in intracellular membranes.Biophysical journal · 1996Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
cAMP-dependent chloride channels in heart contribute to autonomic regulation of action potential duration and membrane potential and have been inferred to be due to cardiac expression of the epithelial cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. In this report, a cDNA from rabbit ventricle was isolated and sequenced, which encodes an exon 5 splice variant (exon 5-) of CFTR, with >90% identity to human CFTR cDNA present in epithelial cells. Expression of this cDNA in Xenopus oocytes gave rise to robust cAMP-activated chloride currents that were absent in control water-injected oocytes. Antisense oligodeoxynucleotides directed against CFTR significantly reduced the density of cAMP-dependent chloride currents in acutely cultured myocytes, thereby establishing a direct functional link between cardiac expression of CFTR protein and an endogenous chloride channel in native cardiac myocytes.
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Registered trials
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