ArticleProceedings of the National Academy of Sciences of the United States of America1996
Cell cycle regulation and cell type-specific localization of the FtsZ division initiation protein in Caulobacter.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 109 citations in OpenAlex.
- Cell cycle dependent coordination of surface layer biogenesis in Caulobacter crescentus.Nature communications · 2024Article
- Synchronized Swarmers and Sticky Stalks: Caulobacter crescentus as a Model for Bacterial Cell Biology.Journal of bacteriology · 2023Review
- Proteolysis dependent cell cycle regulation in Caulobacter crescentus.Cell division · 2022Review
- A specialized MreB-dependent cell wall biosynthetic complex mediates the formation of stalk-specific peptidoglycan in Caulobacter crescentus.PLoS genetics · 2019Article
- Cell cycle-dependent regulation of FtsZ in Escherichia coli in slow growth conditions.Molecular microbiology · 2018Article
- Sizing up the bacterial cell cycle.Nature reviews. Microbiology · 2017Review
- Shapeshifting to Survive: Shape Determination and Regulation in Caulobacter crescentus.Trends in microbiology · 2017Review
- ClpAP is an auxiliary protease for DnaA degradation in Caulobacter crescentus.Molecular microbiology · 2016Article
- The bacterial divisome: ready for its close-up.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- The bacterial tubulin FtsZ requires its intrinsically disordered linker to direct robust cell wall construction.Nature communications · 2015Article
- Size sensors in bacteria, cell cycle control, and size control.Frontiers in microbiology · 2015Review
- Assembly of the Caulobacter cell division machine.Molecular microbiology · 2011Article
- Article
- Regulation of the activity of the dual-function DnaA protein in Caulobacter crescentus.PloS one · 2011Article
- The caulobacter Tol-Pal complex is essential for outer membrane integrity and the positioning of a polar localization factor.Journal of bacteriology · 2010Article
- DipM links peptidoglycan remodelling to outer membrane organization in Caulobacter.Molecular microbiology · 2010Article
- Getting in the loop: regulation of development in Caulobacter crescentus.Microbiology and molecular biology reviews : MMBR · 2010Review
- Bacterial shape: two-dimensional questions and possibilities.Annual review of microbiology · 2010Review
- Bacterial cell division: assembly, maintenance and disassembly of the Z ring.Nature reviews. Microbiology · 2009Review
- Complex regulatory pathways coordinate cell-cycle progression and development in Caulobacter crescentus.Advances in microbial physiology · 2009Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Many genes involved in cell division and DNA replication and their protein products have been identified in bacteria; however, little is known about the cell cycle regulation of the intracellular concentration of these proteins. It has been shown that the level of the tubulin-like GTPase FtsZ is critical for the initiation of cell division in bacteria. We show that the concentration of FtsZ varies dramatically during the cell cycle of Caulobacter crescentus. Caulobacter produce two different cell types at each cell division: (i) a sessile stalked cell that can initiate DNA replication immediately after cell division and (ii) a motile swarmer cell in which DNA replication is blocked. After cell division, only the stalked cell contains FtsZ. FtsZ is synthesized slightly before the swarmer cells differentiate into stalked cells and the intracellular concentration of FtsZ is maximal at the beginning of cell division. Late in the cell cycle, after the completion of chromosome replication, the level of FtsZ decreases dramatically. This decrease is probably mostly due to the degradation of FtsZ in the swarmer compartment of the predivisional cell. Thus, the variation of FtsZ concentration parallels the pattern of DNA synthesis. Constitutive expression of FtsZ leads to defects in stalk biosynthesis suggesting a role for FtsZ in this developmental process in addition to its role in cell division.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.