ArticleNucleic acids research1996
The CtBP binding domain in the adenovirus E1A protein controls CR1-dependent transactivation.
Article in Nucleic acids research, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 78 citations in OpenAlex.
- NAD-linked mechanisms of gene de-repression and a novel role for CtBP in persistent adenovirus infection of lymphocytes.Virology journal · 2019Article
- C-Terminus of E1A Binding Protein 1 Stimulates Malignant Phenotype in Human Hepatocellular Carcinoma.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- ZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin.Nature communications · 2017Article
- C-Terminal Binding Protein: A Molecular Link between Metabolic Imbalance and Epigenetic Regulation in Breast Cancer.International journal of cell biology · 2013Article
- Inhibition of transcriptional activation and cell proliferation activities of adenovirus E1A by the unique N-terminal domain of CtBP2.Oncogene · 2008Article
- Identification of a second CtBP binding site in adenovirus type 5 E1A conserved region 3.Journal of virology · 2008Article
- PLDLS-dependent interaction of E1A with CtBP: regulation of CtBP nuclear localization and transcriptional functions.Oncogene · 2007Article
- CtIP activates its own and cyclin D1 promoters via the E2F/RB pathway during G1/S progression.Molecular and cellular biology · 2006Article
- CtBP/BARS: a dual-function protein involved in transcription co-repression and Golgi membrane fission.The EMBO journal · 2003Article
- CtBP-independent repression in the Drosophila embryo.Molecular and cellular biology · 2003Article
- The adenovirus e3 promoter is sensitive to activation signals in human T cells.Journal of virology · 2003Article
- Interaction between FOG-1 and the corepressor C-terminal binding protein is dispensable for normal erythropoiesis in vivo.Molecular and cellular biology · 2002Article
- The ANGUSTIFOLIA gene of Arabidopsis, a plant CtBP gene, regulates leaf-cell expansion, the arrangement of cortical microtubules in leaf cells and expression of a gene involved in cell-wall formation.The EMBO journal · 2002Article
- Acetylation of nuclear hormone receptor-interacting protein RIP140 regulates binding of the transcriptional corepressor CtBP.Molecular and cellular biology · 2001Article
- SOX6 binds CtBP2 to repress transcription from the Fgf-3 promoter.Nucleic acids research · 2001Article
- Local action of long-range repressors in the Drosophila embryo.The EMBO journal · 2001Article
- Acetylation of adenovirus E1A regulates binding of the transcriptional corepressor CtBP.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Lessons learned from BRCA1 and BRCA2.Oncogene · 2000Review
- The c-Myc-interacting adaptor protein Bin1 activates a caspase-independent cell death program.Oncogene · 2000Article
- Identification of CtBP1 and CtBP2 as corepressors of zinc finger-homeodomain factor deltaEF1.Molecular and cellular biology · 1999Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The adenovirus E1A-243R protein has the ability to force a resting cell into uncontrolled proliferation by modulating the activity of key targets in cell cycle control. Most of these regulatory mechanisms are dependent on activities mapping to conserved region 1 (CR1) and the non-conserved N-terminal region of E1A. We have previously shown that CR1 functions as a very patent transactivator when it is tethered to a promoter through a heterologous DNA binding domain. However, artificial DNA binding was not sufficient to convert full-length E1A-243R to a transactivator. Thus, an additional function(s) of the E1A-243R protein modulates the effect of CR1 in transcription regulation. Here we demonstrate that a 44 amino acid region at the extreme C-terminus of ElA inhibited transactivation by a Gal4-CR1 fusion protein. Inhibition correlated with binding of the nuclear 48 kDa C-terminal binding protein (CtBP), which has been implicated in E1A-mediated suppression of the metastazing potential of tumour cells. This might suggest that CtBP binding can regulate E1A-mediated transformation by modulating CR1-dependent control of transcription.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.