ArticleThe Journal of experimental medicine1996
Translational control of interleukin 2 messenger RNA as a molecular mechanism of T cell anergy.
Article in The Journal of experimental medicine, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 38 citations in OpenAlex.
- Immune reconstitution after autologous hematopoietic transplantation with Lin-, CD34+, Thy-1lo selected or intact stem cell products.International immunopharmacology · 2007Trial
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- Time-resolved assessment of single-cell protein secretion by sequencing.Nature methods · 2023Article
- Toxicological and pharmacological assessment of AGEN1884, a novel human IgG1 anti-CTLA-4 antibody.PloS one · 2018Article
- Article
- Posttranscriptional silencing of effector cytokine mRNA underlies the anergic phenotype of self-reactive T cells.Immunity · 2011Article
- Function of the nucleotide exchange activity of vav1 in T cell development and activation.Science signaling · 2009Article
- Digital NFATc2 activation per cell transforms graded T cell receptor activation into an all-or-none IL-2 expression.PloS one · 2007Article
- Isolation of polysome-bound mRNA from solid tissues amenable for RT-PCR and profiling experiments.RNA (New York, N.Y.) · 2007Article
- Impaired translational response and increased protein kinase PKR expression in T cells from lupus patients.The Journal of clinical investigation · 2000Article
- Inhibition of apoptosis by ionomycin and zinc in peripheral blood mononuclear cells (PBMC) of leprosy patients.Clinical and experimental immunology · 1999Article
- Abnormal intracellular IL-2 and interferon-gamma (IFN-gamma) production as HIV-1-assocated markers of immune dysfunction.Clinical and experimental immunology · 1998Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
T cell stimulation by triggering through the T cell receptor (TCR) in the absence of costimulatory signals or by calcium ionophore induces unresponsiveness in T cells to further stimulation, a phenomenon known as anergy. In freshly isolated T cells, calcium ionophore induces expression of interleukin (IL)-2 messenger (mRNA), but this mRNA is not translated and not loaded with ribosomes. In addition, while plate-bound anti-CD3 stimulation of resting T cells leads to IL-2 mRNA expression and IL-2 secretion, in cells pretreated with calcium ionophore before anti-CD3 stimulation, the IL-2 mRNA remains polysome unloaded and no IL-2 is produced. These observations show that IL-2 expression is controlled at the translational level, by differential ribosome loading. Furthermore, our data suggest that translational control of IL-2 mRNA may be a molecular mechanism by which anergy is attained.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.