ArticleThe Journal of experimental medicine1996
Activation protein 1-dependent transcriptional activation of interleukin 2 gene by Ca2+/calmodulin kinase type IV/Gr.
Article in The Journal of experimental medicine, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 59 citations in OpenAlex.
- Cell signaling and transcriptional regulation of osteoclast lineage commitment, differentiation, bone resorption and diseases.Cell discovery · 2026Review
- Expression, localisation and functional activation of NFAT-2 in normal human skin, psoriasis, and cultured keratocytes.International journal of clinical and experimental medicine · 2009Article
- Calmodulin-dependent phosphatase, kinases, and transcriptional corepressors involved in T-cell activation.Immunological reviews · 2009Review
- Calcium signaling in immune cells.Nature immunology · 2009Review
- CaMKII and CaMKIV mediate distinct prosurvival signaling pathways in response to depolarization in neurons.Molecular and cellular neurosciences · 2007Article
- Alteration of neuronal firing properties after in vivo experience in a FosGFP transgenic mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type.The EMBO journal · 2000Article
- CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo.The Journal of clinical investigation · 2000Article
- The Epstein-Barr virus-induced Ca2+/calmodulin-dependent kinase type IV/Gr promotes a Ca(2+)-dependent switch from latency to viral replication.Journal of virology · 1997Article
- Regulation of microtubule dynamics by Ca2+/calmodulin-dependent kinase IV/Gr-dependent phosphorylation of oncoprotein 18.Molecular and cellular biology · 1997Article
- Cyclosporin A-sensitive induction of the Epstein-Barr virus lytic switch is mediated via a novel pathway involving a MEF2 family member.The EMBO journal · 1997Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Ca2+/calmodulin-dependent protein kinase (CaMK) type IV/Gr is selectively expressed in T lymphocytes and is activated after signaling via the T cell antigen receptor (TCR), indicating that it mediates some of the Ca(2+)-dependent transcriptional events that follow TCR engagement. Here we show that CaMKIV/Gr induces the transcription factor activation protein 1 (AP-1) alone or in synergy with T cell mitogens and with the p21ras oncoprotein. CaMKIV/ Gr signaling is associated with transcriptional activation of c-fos but is independent of p21ras or calcineurin. AP-1 is an integral component of the nuclear factor of activated T cells (NFAT) transcriptional complex, which is required for interleukin 2 gene expression in T cells. We demonstrate that CaMKIV/Gr reconstitutes the capacity of the cytosolic component of NFAT to direct transcription from NFAT sites in non-T cells. These results reveal a central role for CaMKIV/Gr as a Ca(2+)-regulated activator of gene transcription in T lymphocytes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.