ArticleThe Journal of clinical investigation1996
Regulation of cellular proliferation and intimal formation following balloon injury in atherosclerotic rabbit arteries.
Article in The Journal of clinical investigation, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 101 citations in OpenAlex.
- A Metabolic Intravascular Platform to Study FDG Uptake in Vascular Injury.Cardiovascular engineering and technology · 2020Article
- Forging the Fate of Cellular Therapies for Cardiovascular Disease.Circulation research · 2017Review
- 2014 Association of American Physicians George M. Kober Medal. Introduction of Elizabeth G. Nabel.The Journal of clinical investigation · 2014Article
- Nanoparticle drug- and gene-eluting stents for the prevention and treatment of coronary restenosis.Theranostics · 2014Review
- Vascular-directed tissue factor pathway inhibitor overexpression regulates plasma cholesterol and reduces atherosclerotic plaque development.Circulation research · 2009Article
- Nanoparticulate carriers for the treatment of coronary restenosis.International journal of nanomedicine · 2007Review
- Cardiovascular gene delivery: The good road is awaiting.Advanced drug delivery reviews · 2006Review
- Transgene delivery of plasmid DNA to smooth muscle cells and macrophages from a biostable polymer-coated stent.Gene therapy · 2003Article
- Applied gene therapy in preclinical models of vascular injury.Current atherosclerosis reports · 2003Review
- Blockade of human immunodeficiency virus type 1 expression by caveolin-1.Journal of virology · 2002Article
- Gene therapy for restenosis: current status.Drugs · 2002Review
- Nonviral gene transfer strategies for the vasculature.Microcirculation (New York, N.Y. : 1994) · 2002Review
- Effect of percutaneous adenovirus-mediated Gax gene delivery to the arterial wall in double-injured atheromatous stented rabbit iliac arteries.Gene therapy · 2000Article
- Adenovirus-mediated delivery of the Gax transcription factor to rat carotid arteries inhibits smooth muscle proliferation and induces apoptosis.Gene therapy · 1999Article
- Requirements for enhanced transgene expression by untranslated sequences from the human cytomegalovirus immediate-early gene.Molecular medicine (Cambridge, Mass.) · 1998Article
- Transcriptional targeting of replication-defective adenovirus transgene expression to smooth muscle cells in vivo.The Journal of clinical investigation · 1997Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Injury to atherosclerotic arteries induces the expression of growth regulatory genes that stimulate cellular proliferation and intimal formation. Intimal expansion has been reduced in vivo in nonatherosclerotic balloon-injured arteries by transfer of genes that inhibit cell proliferation. It is not known, however, whether vascular cell proliferation can be inhibited after injury in more extensively diseased atherosclerotic arteries. Accordingly, the purpose of this study was to investigate whether expression of recombinant genes in atherosclerotic arteries after balloon injury could inhibit intimal cell proliferation. To test this hypothesis, we examined the response to balloon injury in atherosclerotic rabbit arteries after gene transfer of herpesvirus thymidine kinase gene (tk) and administration of ganciclovir. Smooth muscle cells from hyperlipidemic rabbit arteries infected with adenoviral vectors encoding tk were sensitive to ganciclovir, and bystander killing was observed in vitro. In atherosclerotic arteries, a human placental alkaline phosphatase reporter gene was expressed in intimal and medial smooth muscle cells and macrophages, identifying these cells as targets for gene transfer. Expression of tk in balloon-injured hyperlipidemic rabbit arteries followed by ganciclovir treatment resulted in a 64% reduction in intimal cell proliferation 7 d after gene transfer (P = 0.004), and a 35-49% reduction in internal area 21 d after gene transfer, compared with five different control groups (P < 0.05). Replication of smooth muscle cells and macrophages was inhibited by tk expression and ganciclovir treatment. These findings indicate that transfer of a gene that inhibits cellular proliferation limits the intimal area in balloon-injured atherosclerotic arteries. Molecular approaches to the inhibition of cell proliferation in atherosclerotic arteries constitute a possible treatment for vascular proliferative diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.