ArticleDiabetologia1995
Glomerular epithelial foot processes and filtration slits in IDDM patients.
Article in Diabetologia, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 85 citations in OpenAlex.
- Role of nuclear receptors, lipid metabolism, and mitochondrial function in the pathogenesis of diabetic kidney disease.American journal of physiology. Renal physiology · 2025Review
- Development of an automated estimation of foot process width using deep learning in kidney biopsies from patients with Fabry, minimal change, and diabetic kidney diseases.Kidney international · 2024Article
- Mechanisms of podocyte injury and implications for diabetic nephropathy.Clinical science (London, England : 1979) · 2022Article
- Podocyte Foot Process Effacement Precedes Albuminuria and Glomerular Hypertrophy in CD2-Associated Protein Deficient Mice.Frontiers in medicine · 2021Article
- Volumetric, Nanoscale Optical Imaging of Mouse and Human Kidney via Expansion Microscopy.Scientific reports · 2018Article
- Glomerular Endothelial Cell Stress and Cross-Talk With Podocytes in Early [corrected] Diabetic Kidney Disease.Frontiers in medicine · 2018Review
- Podocyte-specific Nox4 deletion affords renoprotection in a mouse model of diabetic nephropathy.Diabetologia · 2016Article
- Podocyte structural parameters do not predict progression to diabetic nephropathy in normoalbuminuric type 1 diabetic patients.American journal of nephrology · 2015Article
- Molecular and cellular events mediating glomerular podocyte dysfunction and depletion in diabetes mellitus.Frontiers in endocrinology · 2014Review
- Protective effect of erythropoietin on renal injury induced in rats by four weeks of exhaustive exercise.BMC nephrology · 2013Article
- Diabetic kidney disease; review of the current knowledge.Journal of renal injury prevention · 2013Review
- Chronic endothelin-1 infusion elevates glomerular sieving coefficient and proximal tubular albumin reuptake in the rat.Life sciences · 2012Article
- Protective effects of leukemia inhibitory factor against oxidative stress during high glucose-induced apoptosis in podocytes.Cell stress & chaperones · 2012Article
- Interleukin-10 expression induced by adeno-associated virus vector suppresses proteinuria in Zucker obese rats.Gene therapy · 2012Article
- The renin inhibitor aliskiren attenuates high-glucose induced extracellular matrix synthesis and prevents apoptosis in cultured podocytes.Nephron. Experimental nephrology · 2011Article
- Endothelin-1 increases glomerular permeability and inflammation independent of blood pressure in the rat.Hypertension (Dallas, Tex. : 1979) · 2010Article
- Insulin signaling to the glomerular podocyte is critical for normal kidney function.Cell metabolism · 2010Article
- Histopathology of diabetic nephropathy.Seminars in nephrology · 2007Review
- The effect of intrauterine environment and low glomerular number on the histological changes in diabetic glomerulosclerosis.Diabetologia · 2006Article
- Widening of foot processes in normoalbuminuric adolescents with type 1 diabetes.Pediatric nephrology (Berlin, Germany) · 2005Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetic nephropathy is associated with functional changes in the glomerular filtration barrier but the structural counterpart remains unknown. Width of glomerular epithelial cell foot processes and of filtration slits were determined by morphometric methods in 11 non-diabetic kidney donors and in 28 diabetic patients with albumin excretion rates ranging from normal to proteinuria. Foot process width was estimated from the ratio of tuft surface density to length density of slits. At high magnification independently sampled, perpendicularly cut slits were classified. Foot process width on peripheral basement membrane was increased in microalbuminuric compared to normoalbuminuric diabetic patients (p<0.05) but showed no significant correlation with the level of albumin excretion when patients with increased barrier permeability were considered. Width of filtration slits in normo- and microalbuminuric diabetic patients exceeded that in non-diabetic control subjects (p<0.05). Filtration slits were narrower in patients with overt proteinuria than in patients with microalbuminuria (p<0.05) and correlated with glomerular filtration rate in all of the diabetic patients (r=0.65, p<0.005). The results show that insulin-dependent diabetic patients with nephropathy present changes of epithelial cells and filtration slits, demonstrable already in the stage of microalbuminuria. The mechanism of albumin leakage is not achieved by these measures. The dimension of filtration slits may play a contributing role in the level of glomerular filtration rate in diabetic patients.
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