ArticleBMJ (Clinical research ed.)1996
Sex related differences in short and long-term prognosis after acute myocardial infarction: 10 year follow up of 3073 patients in database of first Danish Verapamil Infarction Trial.
Article in BMJ (Clinical research ed.), 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sex differences in long-term mortality after myocardial infarction: a systematic review.Circulation · 2014Pooled it
- Sex Differences in Outcomes After Myocardial Infarction in the Community.The American journal of medicine · 2021Article
- Acute coronary syndrome in young women under 55 years of age: clinical characteristics, treatment, and outcomes.Clinical research in cardiology : official journal of the German Cardiac Society · 2015Observational
- Impact of the joint association between sex, age and diabetes on long-term mortality after acute myocardial infarction.BMC public health · 2015Article
- Gender differences in contrast-enhanced magnetic resonance imaging after acute myocardial infarction.The international journal of cardiovascular imaging · 2013Article
- Role of age and sex in short-term and long term mortality after a first Q wave myocardial infarction.Journal of epidemiology and community health · 2001Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo re-examine the prevailing hypothesis that women fare worse than men after acute myocardial infarction.
design10 year follow up of all patients with confirmed acute myocardial infarction registered in the database of the Danish verapamil infarction trial in 1979-81.
setting16 coronary care units, covering a fifth of the total Danish population. PATIENTS: 3073 consecutive patients with acute myocardial infarction, 738 (24%) women and 2335 (76%) men.
main outcome measuresEarly mortality (before day 15). For patients alive on day 15: mortality, cause of death, admission with recurrent infarction, and mortality after reinfarction.
resultsEarly mortality increased significantly with age (P < 0.0001) but was not significantly related to sex, with a 15 day mortality of 17% in women and 16% in men. Adjustment for age and sex simultaneously revealed a significant interaction (P = 0.02) between these variables, with a greater increase with age in early mortality for men than for women (early mortality was equal for the two sexes at age 64 years). Ten year mortality in patients alive on day 15 was 58.8%. The overall age adjusted hazard ratio (95% confidence interval) for women versus men was 0.90 (0.80 to 1.01); 0.90 (0.78 to 1.04) for 10 year reinfarction (48.8%); and 0.98 (0.82 to 1.16) for 10 year mortality after reinfarction (82.3%). No difference in cause of death was found between the sexes. With a follow up of up to 10 years for patients alive on day 15 mortality, rate of reinfarction, and mortality after reinfarction increased with increasing age (P < 0.0001).
conclusionSex by itself is not a risk factor after acute myocardial infarction.
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