ArticleJournal of assisted reproduction and genetics1996
Polar body diagnosis of common aneuploidies by FISH.
Article in Journal of assisted reproduction and genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 86 citations in OpenAlex.
- Preimplantation diagnosis by fluorescence in situ hybridization using 13-, 16-, 18-, 21-, 22-, X-, and Y-chromosome probes.Journal of assisted reproduction and genetics · 1999Trial
- Preimplantation genetic diagnosis for couples at high risk of Down syndrome pregnancy owing to parental translocation or mosaicism.Journal of medical genetics · 1999Trial
- Oocyte Health and Quality: Implication of Mitochondria-related Organelle Interactions.Results and problems in cell differentiation · 2024Review
- The Effect of Preimplantation Genetic Screening on Implantation Rate in Women over 35 Years of Age.Cell journal · 2016Article
- A review of, and commentary on, the ongoing second clinical introduction of preimplantation genetic screening (PGS) to routine IVF practice.Journal of assisted reproduction and genetics · 2012Review
- Advantages of day 4 embryo transfer in patients undergoing preimplantation genetic diagnosis of aneuploidy.Journal of assisted reproduction and genetics · 1999Article
- Preimplantation diagnosis of common aneuploidies by the first- and second-polar body FISH analysis.Journal of assisted reproduction and genetics · 1998Article
- Demystified ... FISH.Molecular pathology : MP · 1998Review
- Association between nondisjunction and maternal age in meiosis-II human oocytes.American journal of human genetics · 1996Article
- Preimplantation genetic diagnosis.Journal of assisted reproduction and genetics · 1996Article
- Reduction in signal overlap results in increased FISH efficiency: implications for preimplantation genetic diagnosis.Journal of assisted reproduction and genetics · 1996Article
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this work was to investigate the reliability and accuracy of polar body analysis for preimplantation diagnosis of common aneuploidies in IVF patients of advanced maternal age.
designWe have previously introduced polar body analysis as an approach for nondestractive evaluation of the genotype of human oocytes. The method has recently been applied in a clinical trial involving 45 infertile patients, demonstrating the feasibility of preconception diagnosis of common aneuploidies by fluorescent in situ hybridization (FISH). The present paper describes the experience of polar body diagnosis in 135 IVF patients (161 cycles) of advanced maternal age.
resultsFISH results of the first and/or second polar bodies were available in 648 (72.4%) of 895 biopsied oocytes subjected to FISH analysis. Of 648 oocytes with FISH results, 208 demonstrated chromosomal abnormalities. Of 440 oocytes predicted to be free from monosomy or trisomy of chromosomes X, 18, and/or 13/21, 314 were normally fertilized, cleaved, and transferred in 122 treatment cycles, resulting in 6 healthy deliveries and 12 ongoing pregnancies following confirmation of the polar body diagnosis by CVS or amniocentesis.
conclusionsThe method may be useful for detection of oocytes with common chromosomal trisomies in IVF patients of advanced maternal age.
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