ArticleMolecular biology of the cell1996
Identification and developmental regulation of a neuron-specific subunit of cytoplasmic dynein.
Article in Molecular biology of the cell, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 60 citations in OpenAlex.
- Review
- Molecular Basis for the Protein Recognition Specificity of the Dynein Light Chain DYNLT1/Tctex1: CHARACTERIZATION OF THE INTERACTION WITH ACTIVIN RECEPTOR IIB.The Journal of biological chemistry · 2016Article
- Distinct functional roles of cytoplasmic dynein defined by the intermediate chain isoforms.Experimental cell research · 2015Review
- Live cell imaging reveals differential modifications to cytoplasmic dynein properties by phospho- and dephosphomimic mutations of the intermediate chain 2C S84.Journal of neuroscience research · 2014Article
- The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Epidermal growth factor stimulates extracellular-signal regulated kinase phosphorylation of a novel site on cytoplasmic Dynein intermediate chain 2.International journal of molecular sciences · 2013Article
- Trk activation of the ERK1/2 kinase pathway stimulates intermediate chain phosphorylation and recruits cytoplasmic dynein to signaling endosomes for retrograde axonal transport.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Behavioral and other phenotypes in a cytoplasmic Dynein light intermediate chain 1 mutant mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Article
- Structure-function-folding relationships and native energy landscape of dynein light chain protein: nuclear magnetic resonance insights.Journal of biosciences · 2009Review
- A neuron-specific cytoplasmic dynein isoform preferentially transports TrkB signaling endosomes.The Journal of cell biology · 2008Article
- Action in the axon: generation and transport of signaling endosomes.Current opinion in neurobiology · 2008Review
- Genetic analysis of the cytoplasmic dynein subunit families.PLoS genetics · 2006Article
- The offloading model for dynein function: differential function of motor subunits.The Journal of cell biology · 2005Article
- The Drosophila tctex-1 light chain is dispensable for essential cytoplasmic dynein functions but is required during spermatid differentiation.Molecular biology of the cell · 2004Article
- Dynactin is required for bidirectional organelle transport.The Journal of cell biology · 2003Article
- Subunit organization in cytoplasmic dynein subcomplexes.Protein science : a publication of the Protein Society · 2002Article
- Subunit heterogeneity of cytoplasmic dynein: Differential expression of 14 kDa dynein light chains in rat hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Cytoplasmic dynein intermediate-chain isoforms with different targeting properties created by tissue-specific alternative splicing.Molecular and cellular biology · 1998Article
- Identification of a microtubule-associated motor protein essential for dendritic differentiation.The Journal of cell biology · 1997Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytoplasmic dynein is the microtubule minus-end-directed motor for the retrograde axonal transport of membranous organelles. Because of its similarity to the intermediate chains of flagellar dynein, the 74-kDa intermediate chain (IC74) subunit of dynein is thought to be involved in binding dynein to its membranous organelle cargo. Previously, we identified six isoforms of the IC74 cytoplasmic dynein subunit in the brain. We further demonstrated that cultured glia and neurons expressed different dynein IC74 isoforms and phospho-isoforms. Two isoforms were observed when dynein from glia was analyzed. When dynein from cultured neurons was analyzed, six IC74 isoforms were observed, although the relative amounts of the dynein isoforms from cultured neurons differed from those found in dynein from brain. To better understand the role of the neuronal IC74 isoforms and identify neuron-specific IC74 dynein subunits, the expression of the IC74 protein isoforms and mRNAs of various tissues were compared. As a result of this comparison, the identity of each of the isoform spots observed on two-dimensional gels was correlated with the products of each of the IC74 mRNAs. We also found that between the fifteenth day of gestation (E15) and the fifth day after birth (P5), the relative expression of the IC74 protein isoforms changes, demonstrating that the expression of IC74 isoforms is developmentally regulated in brain. During this time period, there is relatively little change in the abundance of the various IC74 mRNAs. The E15 to P5 time period is one of rapid process extension and initial pattern formation in the rat brain. This result indicates that the changes in neuronal IC74 isoforms coincide with neuronal differentiation, in particular the extension of processes. This suggests a role for the neuronal IC74 isoforms in the establishment or regulation of retrograde axonal transport.
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