ArticleMolecular biology of the cell1996
Drosophila MCM protein complexes.
Article in Molecular biology of the cell, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 58 citations in OpenAlex.
- RNA-seq analysis reveals changes in mRNA expression during development in Daphnia mitsukuri.BMC genomics · 2024Article
- Proteins rather than mRNAs regulate nucleation and persistence of Oskar germ granules in Drosophila.Cell reports · 2023Article
- Article
- Bacteriocyte Reprogramming to Cope With Nutritional Stress in a Phloem Sap Feeding Hemipteran, the Pea AphidFrontiers in physiology · 2018Article
- Mechanisms and regulation of DNA replication initiation in eukaryotes.Critical reviews in biochemistry and molecular biology · 2017Review
- Characterization of a Drosophila ortholog of the Cdc7 kinase: a role for Cdc7 in endoreplication independent of Chiffon.The Journal of biological chemistry · 2015Article
- The Mcm complex: unwinding the mechanism of a replicative helicase.Microbiology and molecular biology reviews : MMBR · 2009Review
- A genetic analysis of the Drosophila mcm5 gene defines a domain specifically required for meiotic recombination.Genetics · 2007Article
- The Epstein-Barr virus-encoded LMP-1 oncoprotein negatively affects Tyk2 phosphorylation and interferon signaling in human B cells.Journal of virology · 2006Article
- REC, Drosophila MCM8, drives formation of meiotic crossovers.PLoS genetics · 2005Article
- SNR1 (INI1/SNF5) mediates important cell growth functions of the Drosophila Brahma (SWI/SNF) chromatin remodeling complex.Genetics · 2004Article
- Human Mcm proteins at a replication origin during the G1 to S phase transition.Nucleic acids research · 2002Article
- Drosophila minichromosome maintenance 6 is required for chorion gene amplification and genomic replication.Molecular biology of the cell · 2002Article
- Nearest neighbour analysis of MCM protein complexes in Drosophila melanogaster.Nucleic acids research · 2001Article
- Identification of Cdc6 protein domains involved in interaction with Mcm2 protein and Cdc4 protein in budding yeast cells.The Biochemical journal · 2001Article
- Drosophila double parked: a conserved, essential replication protein that colocalizes with the origin recognition complex and links DNA replication with mitosis and the down-regulation of S phase transcripts.Genes & development · 2000Article
- Sequential MCM/P1 subcomplex assembly is required to form a heterohexamer with replication licensing activity.The Journal of biological chemistry · 2000Article
- Drosophila ORC specifically binds to ACE3, an origin of DNA replication control element.Genes & development · 1999Article
- ORC localization in Drosophila follicle cells and the effects of mutations in dE2F and dDP.Genes & development · 1999Article
- Chromosome association of minichromosome maintenance proteins in Drosophila endoreplication cycles.The Journal of cell biology · 1998Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
MCM genes encode a family of evolutionarily conserved proteins required for DNA replication. In Saccharomyces cerevisiae, where they were first identified, MCM genes interact genetically with each other. Allele specificity in these interactions suggests that MCM proteins physically associate with one another and that this association is essential for function. We describe here an analysis of physical interactions among three Drosophila MCM proteins. Using specific antibodies we detect Drosophila MCMs almost exclusively in 600-kDa protein complexes. Co-immunoprecipitation data demonstrate the existence of at least two distinct types of 600-kDa complexes, one that contains DmCDC46 and one that appears to contain both DmMCM2 and Dpa (a CDC54 homologue). These complexes are stable throughout embryonic division cycles, are resistant to treatments with salt and detergent, and are present during development in tissues undergoing mitotic DNA replication as well as endoreplication. When extracts are prepared under low salt conditions all three MCM proteins co-immunoprecipitate. Consequently, we suggest that the 600-kDa complexes interact in a higher order complex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.