ArticleBritish journal of cancer1996
Prognostic significance of p53 overexpression and mutation in colorectal adenocarcinomas.
Article in British journal of cancer, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Making Connections: p53 and the Cathepsin Proteases as Co-Regulators of Cancer and Apoptosis.Cancers · 2020Review
- Overexpression of TP53 protein is associated with the lack of adjuvant chemotherapy benefit in patients with stage III colorectal cancer.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2020Article
- High Expression of Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2) in Esophageal Squamous Cell Carcinoma and its Clinical Prognostic Significance.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Mechanism of Apoptosis Induced by Curcumin in Colorectal Cancer.International journal of molecular sciences · 2019Review
- The expression of multiple proteins as prognostic factors in colorectal cancer: cathepsin D, p53, COX-2, epidermal growth factor receptor, C-erbB-2, and Ki-67.Gut and liver · 2014Article
- Prognostic significance of p53-expression in colorectal carcinoma as measured by a luminometric immunoassay.German medical science : GMS e-journal · 2010Article
- Relationship between VEGF and p53 expression and tumor cell proliferation in human gastrointestinal carcinomas.Journal of cancer research and clinical oncology · 2008Article
- Molecular lesions in colorectal cancer: impact on prognosis? Original data and review of the literature.International journal of colorectal disease · 2004Review
- High incidence of protein-truncating mutations of the p53 gene in liver metastases of colorectal carcinomas.Oncogene · 2002Article
- What we could do now: molecular pathology of colorectal cancer.Molecular pathology : MP · 2001Review
- Prostate tumours from an Asian population: examination of bax, bcl-2, p53 and ras and identification of bax as a prognostic marker.British journal of cancer · 2000Article
- Thymidilate synthase and p53 primary tumour expression as predictive factors for advanced colorectal cancer patients.British journal of cancer · 2000Article
- p53 protein accumulation and p53 gene mutation in colorectal cancer.Pathology oncology research : POR · 2000Article
- Increased serum p53 antibody levels indicate poor prognosis in patients with colorectal cancer.British journal of cancer · 1998Article
- Genetic prognostic markers in colorectal cancer.Molecular pathology : MP · 1997Review
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The p53 tumour-suppressor gene is found altered in the majority of colorectal cancers. Lesions include allelic loss, mutation of the gene and overexpression of the p53 protein. All of these lesions have been analysed for prognostic significance, and whereas both mutation and allelic loss have been shown to be reasonably useful markers of prognosis, the utility of overexpression of the p53 protein is more ambiguous. Given that many authors use p53 overexpression as a marker for point mutation this issue is of some importance. We have therefore examined 100 colorectal carcinomas for mutation of the p53 gene, as well as overexpression of the p53 protein. Results show that whereas mutation of the p53 gene is associated with p53 overexpression, the degree of association depends, at least in part, upon the particular antibody used. Moreover, although mutation of the p53 gene does provide prognostic information, overexpression of the p53 protein, as detected with two antibodies, does not. These results suggest that immunohistochemistry is not a suitable alternative to direct detection of mutation in assessing prognosis in colorectal cancer patients.
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