ArticleThe American journal of pathology1996
Tissue factor expression during human and mouse development.
Article in The American journal of pathology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 100 citations in OpenAlex.
- Coagulation signaling from amniotic fluid to fetal skin.Blood advances · 2022Article
- Adult human pancreatic acinar cells dedifferentiate into an embryonic progenitor-like state in 3D suspension culture.Scientific reports · 2019Article
- Coagulation factor 9-deficient mice are protected against dextran sulfate sodium-induced colitis.Biology open · 2018Article
- Progress and perspectives on targeting nanoparticles for brain drug delivery.Acta pharmaceutica Sinica. B · 2016Review
- The production of multi-transgenic pigs: update and perspectives for xenotransplantation.Transgenic research · 2016Review
- Inflammation in AKI: Current Understanding, Key Questions, and Knowledge Gaps.Journal of the American Society of Nephrology : JASN · 2016Review
- Tissue factor, protease activated receptors and pathologic heart remodelling.Thrombosis and haemostasis · 2014Review
- Role of the protein C receptor in cancer progression.Thrombosis research · 2014Review
- Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation.Blood · 2013Article
- Article
- Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells.Nature biotechnology · 2011Article
- The endothelial protein C receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors.The Journal of biological chemistry · 2011Article
- Tissue factor, blood coagulation, and beyond: an overview.International journal of inflammation · 2011Article
- Involvement of human decidual cell-expressed tissue factor in uterine hemostasis and abruption.Thrombosis research · 2009Review
- Role of tissue factor in cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2009Review
- Progestin and thrombin regulate tissue factor expression in human term decidual cells.The Journal of clinical endocrinology and metabolism · 2009Article
- Tissue factor-dependent coagulation contributes to alpha-naphthylisothiocyanate-induced cholestatic liver injury in mice.American journal of physiology. Gastrointestinal and liver physiology · 2009Article
- Article
- Transcriptional program of bone morphogenetic protein-2-induced epithelial and smooth muscle differentiation of pluripotent human embryonal carcinoma cells.Functional & integrative genomics · 2005Article
- Efficient male and female germline transmission of a human chromosomal vector in mice.Genome research · 2001Article
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 2 countries.
Funding
Abstract
In the adult organism the cellular distribution of tissue factor (TF) expression corresponds to biological boundary layers forming a hemostatic barrier ready to activate blood coagulation after tissue injury. Whether TF expression might also play a role in development is unknown. To determine the significance of TF in ontogenesis, we examined the pattern of TF expression in mouse development and compared it with the distribution of TF in human post-implantation embryos and fetuses of corresponding gestational age. At early embryonic periods of murine (6.5 and 7.5 pc) and human (stage 5) development, there was strong expression of TF in both ectodermal and entodermal cells. In situ hybridization and immunohistochemistry demonstrated that TF mRNA and protein were expressed widely in epithelial areas with high levels of morphogenic activity during organogenesis. Staining for TF was seen during ontogenetic development in tissues such as epidermis, myocardium, bronchial epithelium, and hepatocytes, which express TF in the adult organism. Surprisingly, during renal development and in adults, expression of TF differed between humans and mice. In humans, maturing stage glomeruli were stained for TF whereas in mice, TF was absent from glomeruli but was present in the epithelia of tubular segments. In neuroepithelial cells, there was a substantial expression of TF. Moreover, there was robust TF expression in tissues such as skeletal muscle and pancreas, which do not express it in the adult. In contrast, expression of the physiological ligand for TF, factor VII, was not detectable during early stages of human embryogenesis using immunohistochemistry. The temporal and spatial pattern of TF expression during murine and human development supports the contention that TF serves as an important morphogenic factor during embryogenesis.
Indexed as
Identifiers
8686734PMC1865244W2220166796What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.