ArticleThe Journal of cell biology1996
A novel suppressor of ras1 in fission yeast, byr4, is a dosage-dependent inhibitor of cytokinesis.
Article in The Journal of cell biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 95 citations in OpenAlex.
- MOB-mediated regulation of septation initiation network (SIN) signaling is required for echinocandin-induced hyperseptation inmSphere · 2024Article
- A role for the carbon source of the cell and protein kinase A in regulating the S. pombe septation initiation network.Journal of cell science · 2024Article
- Budding YeastG3 (Bethesda, Md.) · 2018Article
- Involvement of the septation initiation network in events during cytokinesis in fission yeast.Journal of cell science · 2018Article
- Article
- Cdk1 promotes cytokinesis in fission yeast through activation of the septation initiation network.Molecular biology of the cell · 2014Article
- Dynamics of SIN asymmetry establishment.PLoS computational biology · 2013Article
- Polar opposites: Fine-tuning cytokinesis through SIN asymmetry.Cytoskeleton (Hoboken, N.J.) · 2012Review
- The fission yeast septation initiation network (SIN) kinase, Sid2, is required for SIN asymmetry and regulates the SIN scaffold, Cdc11.Molecular biology of the cell · 2012Article
- Predicting the fission yeast protein interaction network.G3 (Bethesda, Md.) · 2012Article
- Article
- SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.Current biology : CB · 2011Article
- Dividing the spoils of growth and the cell cycle: The fission yeast as a model for the study of cytokinesis.Cytoskeleton (Hoboken, N.J.) · 2011Review
- Dma1 ubiquitinates the SIN scaffold, Sid4, to impede the mitotic localization of Plo1 kinase.The EMBO journal · 2011Article
- Monitoring spindle orientation: Spindle position checkpoint in charge.Cell division · 2010Article
- Timely septation requires SNAD-dependent spindle pole body localization of the septation initiation network components in the filamentous fungus Aspergillus nidulans.Molecular biology of the cell · 2009Article
- Different levels of Bfa1/Bub2 GAP activity are required to prevent mitotic exit of budding yeast depending on the type of perturbations.Molecular biology of the cell · 2008Article
- Nuc2p, a subunit of the anaphase-promoting complex, inhibits septation initiation network following cytokinesis in fission yeast.PLoS genetics · 2008Article
- Modeling the septation initiation network (SIN) in fission yeast cells.Current genetics · 2007Article
- Regulation of gene expression and cell division by Polo-like kinases.Current genetics · 2006Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A novel gene, designated byr4, was identified in Schizosaccharomyces pombe that affects the mitotic cell cycle and shows genetic interactions with the ras1 signaling pathways. Null alleles of byr4 cause cell cycle arrest in late mitosis and permit multiple rounds of septation. The multiple septa typically divide two nuclei, but the nuclei frequently do not stain equally with 4',6-diamidino-2-phenylindole (DAPI), suggesting that byr4 is required for proper karyokinesis. Overexpression of byr4 inhibits cytokinesis, but cell cycle progression continues leading to multinucleate cells. When byr4 is overexpressed, the early steps in the cytokinesis pathway, including formation of the medial F-actin ring, occur normally; however, the later steps in the pathway, including contraction of the F-actin ring, septation, and rearrangement of the medial F-actin following mitosis, rarely occur, byr4 shows two genetic interactions with ras1. The inhibition of cytokinesis by byr4 overexpression was exacerbated by null alleles of ras1 and scd1, suggesting a link between pathways needed for cell polarity and cytokinesis. Overexpression of byr4 also partially bypasses the need for ras1 for sporulation. The electrophoretic mobility of the byr4 protein varied in response to mutants that perturb cytokinesis and karyokinesis, suggesting interactions between byr4 and these gene products. A more rapidly migrating byr4 protein was found in cells with mutations in cdc16, which undergo repeated septation, and in cdc15, which fail to form a medial F-actin ring in mitosis. A slower migrating byr4 protein was found in cells with a mutation in the beta-tubulin gene, which arrests cells at the metaphase-anaphase transition.
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