ArticleThe Journal of cell biology1996
Actin organization, bristle morphology, and viability are affected by actin capping protein mutations in Drosophila.
Article in The Journal of cell biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
49 citing papers in PubMed, 102 citations in OpenAlex.
- Shaping Drosophila eggs: unveiling the roles of Arpc1 and cpb in morphogenesis.Functional & integrative genomics · 2024Article
- The actin cytoskeleton plays multiple roles in structural colour formation in butterfly wing scales.Nature communications · 2024Article
- Heterozygous CAPZA2 mutations cause global developmental delay, hypotonia with epilepsy: a case report and the literature review.Journal of human genetics · 2024Review
- Construction and Analysis of Coexpression Network to Understand Biological Responses in Chickens Infected byFrontiers in veterinary science · 2021Article
- PIM1 accelerates prostate cancer cell motility by phosphorylating actin capping proteins.Cell communication and signaling : CCS · 2020Article
- Variants in CAPZA2, a member of an F-actin capping complex, cause intellectual disability and developmental delay.Human molecular genetics · 2020Article
- Pharmaco-Genetic Screen To Uncover Actin Regulators Targeted by Prostaglandins DuringG3 (Bethesda, Md.) · 2019Article
- Article
- Expression pattern of prohibitin, capping actin protein of muscle Z-line beta subunit and tektin-2 gene in Murrah buffalo sperm and its relationship with sperm motility.Asian-Australasian journal of animal sciences · 2018Article
- MoCAP proteins regulated by MoArk1-mediated phosphorylation coordinate endocytosis and actin dynamics to govern development and virulence of Magnaporthe oryzae.PLoS genetics · 2017Article
- CAPZA1 modulates EMT by regulating actin cytoskeleton remodelling in hepatocellular carcinoma.Journal of experimental & clinical cancer research : CR · 2017Article
- IKKε inhibits PKC to promote Fascin-dependent actin bundling.Development (Cambridge, England) · 2016Article
- Actin capping protein CAPZB regulates cell morphology, differentiation, and neural crest migration in craniofacial morphogenesis†.Human molecular genetics · 2016Article
- Expression of F-actin-capping protein subunit beta, CAPZB, is associated with cell growth and motility in epithelioid sarcoma.BMC cancer · 2016Article
- Preliminary Proteomic Analysis of A549 Cells Infected with Avian Influenza Virus H7N9 and Influenza A Virus H1N1.PloS one · 2016Article
- The availability of filament ends modulates actin stochastic dynamics in live plant cells.Molecular biology of the cell · 2014Article
- Subunits of the Drosophila actin-capping protein heterodimer regulate each other at multiple levels.PloS one · 2014Article
- Prognostic value of CAPZA1 overexpression in gastric cancer.International journal of oncology · 2013Article
- Capping protein modulates the dynamic behavior of actin filaments in response to phosphatidic acid in Arabidopsis.The Plant cell · 2012Article
- The interaction of capping protein with the barbed end of the actin filament.Journal of molecular biology · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Regulation of actin filament length and orientation is important in many actin-based cellular processes. This regulation is postulated to occur through the action of actin-binding proteins. Many actin-binding proteins that modify actin in vitro have been identified, but in many cases, it is not known if this activity is physiologically relevant. Capping protein (CP) is an actin-binding protein that has been demonstrated to control filament length in vitro by binding to the barbed ends and preventing the addition or loss of actin monomers. To examine the in vivo role of CP, we have performed a molecular and genetic characterization of the beta subunit of capping protein from Drosophila melanogaster. We have identified mutations in the Drosophila beta subunit-these are the first CP mutations in a multicellular organism, and unlike CP mutations in yeast, they are lethal, causing death during the early larval stage. Adult files that are heterozygous for a pair of weak alleles have a defect in bristle morphology that is correlated to disorganized actin bundles in developing bristles. Our data demonstrate that CP has an essential function during development, and further suggest that CP is required to regulate actin assembly during the development of specialized structures that depend on actin for their morphology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.