ArticleThe Journal of cell biology1996
Nic96p is required for nuclear pore formation and functionally interacts with a novel nucleoporin, Nup188p.
Article in The Journal of cell biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed, 103 citations in OpenAlex.
- Multifunctional roles of Brl1-Brr6 in nuclear envelope fusion during nuclear pore complex biogenesis.The EMBO journal · 2026Article
- Genomic Insights intoJournal of fungi (Basel, Switzerland) · 2026Article
- Article
- Decreased mechanotransduction prevents nuclear collapse in aProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Expression of TorsinA in a heterologous yeast system reveals interactions with lumenal domains of LINC and nuclear pore complex components.Molecular biology of the cell · 2019Article
- Identification of the NovelG3 (Bethesda, Md.) · 2018Article
- Fantastic nuclear envelope herniations and where to find them.Biochemical Society transactions · 2018Review
- The yeast Ty1 retrotransposon requires components of the nuclear pore complex for transcription and genomic integration.Nucleic acids research · 2018Article
- Chm7 and Heh1 collaborate to link nuclear pore complex quality control with nuclear envelope sealing.The EMBO journal · 2016Article
- Neuronal Nuclear Membrane Budding Occurs during a Developmental Window Modulated by Torsin Paralogs.Cell reports · 2016Article
- Interactome Mapping Reveals the Evolutionary History of the Nuclear Pore Complex.PLoS biology · 2016Article
- The transmission of nuclear pore complexes to daughter cells requires a cytoplasmic pool of Nsp1.The Journal of cell biology · 2013Article
- Functional insights from studies on the structure of the nuclear pore and coat protein complexes.Cold Spring Harbor perspectives in biology · 2013Review
- Tandem fluorescent protein timers for in vivo analysis of protein dynamics.Nature biotechnology · 2012Article
- The C-terminal domain of Nup93 is essential for assembly of the structural backbone of nuclear pore complexes.Molecular biology of the cell · 2012Article
- Lumenal interactions in nuclear pore complex assembly and stability.Molecular biology of the cell · 2011Article
- Changes in the nuclear envelope environment affect spindle pole body duplication in Saccharomyces cerevisiae.Genetics · 2010Article
- The nucleoporin Nup188 controls passage of membrane proteins across the nuclear pore complex.The Journal of cell biology · 2010Article
- Pom33, a novel transmembrane nucleoporin required for proper nuclear pore complex distribution.The Journal of cell biology · 2010Article
- Architectural nucleoporins Nup157/170 and Nup133 are structurally related and descend from a second ancestral element.The Journal of biological chemistry · 2009Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The amino-terminal domain of Nic96p physically interacts with the Nsp1p complex which is involved in nucleocytoplasmic transport. Here we show that thermosensitive mutations mapping in the central domain of Nic96p inhibit nuclear pore formation at the nonpermissive temperature. Furthermore, the carboxyterminal domain of Nic96p functionally interacts with a novel nucleoporin Nup188p in an allele-specific fashion, and when ProtA-Nup188p was affinity purified, a fraction of Nic96p was found in physical interaction. Although NUP188 is not essential for viability, a null mutant exhibits striking abnormalities in nuclear envelope and nuclear pore morphology. We propose that Nic96p is a multivalent protein of the nuclear pore complex linked to several nuclear pore proteins via its different domains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.