ArticleJournal of bacteriology1996
Population genetic analysis of Helicobacter pylori by multilocus enzyme electrophoresis: extensive allelic diversity and recombinational population structure.
Article in Journal of bacteriology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
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Who cites it
74 citing papers in PubMed.
- Genetic variation in the cag pathogenicity island of Helicobacter pylori strains detected from gastroduodenal patients in Thailand.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020Article
- Article
- The hypothesis that Helicobacter pylori predisposes to Alzheimer's disease is biologically plausible.Scientific reports · 2017Article
- Genomic structure and insertion sites of Helicobacter pylori prophages from various geographical origins.Scientific reports · 2017Article
- Gastroretentive drug delivery systems for the treatment of Helicobacter pylori.World journal of gastroenterology · 2014Review
- Genome Sequence of a Helicobacter pylori Strain Isolated from a Mexican Patient with Intestinal Gastric Cancer.Genome announcements · 2014Article
- Effect of Helicobacter pylori cdrA on interleukin-8 secretions and nuclear factor kappa B activation.World journal of gastroenterology · 2012Article
- The Helicobacter pylori cag Pathogenicity Island.Methods in molecular biology (Clifton, N.J.) · 2012Review
- Genetic manipulation of a naturally competent bacterium, Helicobacter pylori.Methods in molecular biology (Clifton, N.J.) · 2012Article
- Multiple infection and microdiversity among Helicobacter pylori isolates in a single host in India.PloS one · 2012Article
- Molecular evolution of the Helicobacter pylori vacuolating toxin gene vacA.Journal of bacteriology · 2010Article
- Role of innate immunity in Helicobacter pylori-induced gastric malignancy.Physiological reviews · 2010Review
- Pan-genome analysis provides much higher strain typing resolution than multi-locus sequence typing.Microbiology (Reading, England) · 2010Article
- Repeat-associated plasticity in the Helicobacter pylori RD gene family.Journal of bacteriology · 2009Article
- Delineation of a carcinogenic Helicobacter pylori proteome.Molecular & cellular proteomics : MCP · 2009Article
- Prevalence of virulence-associated genotypes of Helicobacter pylori and correlation with severity of gastric pathology in patients from western Sicily, Italy.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2009Article
- Mosaic DNA imports with interspersions of recipient sequence after natural transformation of Helicobacter pylori.PloS one · 2008Article
- Genetic microheterogeneity and phenotypic variation of Helicobacter pylori arginase in clinical isolates.BMC microbiology · 2007Article
- Genotypic, phenotypic, and clinical characteristics of isolates of Helicobacter pylori from San Luis, Argentina.Folia microbiologica · 2007Article
- Genomic changes during chronic Helicobacter pylori infection.Journal of bacteriology · 2006Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic diversity and relationships in 74 Helicobacter pylori isolates recovered from patients assigned to distinct clinical categories were estimated by examination of allelic variation in six genes encoding metabolic housekeeping enzymes by multilocus enzyme electrophoresis. Seventy-three distinct allele profiles, representing multilocus chromosomal genotypes, were identified. All six loci were highly polymorphic, with an average of 11.2 alleles per locus. The mean genetic diversity in the sample was 0.735, a value that exceeds the level of diversity recorded in virtually all bacterial species studied by multilocus enzyme electrophoresis. A high frequency of occurrence of null alleles (lack of enzyme activity) was identified and warrants further investigation at the molecular level. Lack of linkage disequilibrium (nonrandom association (of alleles over loci) indicates that horizontal transfer and recombination of metabolic enzyme genes have contributed to the generation of chromosomal diversity in H. pylori. In this sample of isolates, there was no statistically significant association of multilocus enzyme electrophoretic types or cluster of related chromosomal types and disease category.
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