ReviewMolecular biotechnology1995
Two-dimensional DNA typing: A cost-effective way of analyzing complex mixtures of DNA fragments for sequence variations.
Review in Molecular biotechnology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- DNA fingerprinting techniques for microorganisms. A proposal for classification and nomenclature.Molecular biotechnology · 1996Review
- Multiplex co-amplification of 24 retinoblastoma gene exons after pre-amplification by long-distance PCR.Nucleic acids research · 1996Article
Corrections and comments
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Authors and funding
1 author.
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Abstract
By two-dimensional (2D) DNA typing, multiple DNA fragments can be analyzed in parallel for all possible sequence variations. The method involves electrophoretic separation in polyacrylamide gels, first by size and subsequently on the basis of basepair sequence in a denaturing gradient. The system has been automated partly and a dedicated image analysis system for rapid interpretation of the often complex spot patterns was developed. In this review, the basic principles of 2D DNA typing, its methodology, and some major applications in genetic studies of animals, plants, and microorganisms will be discussed, with the emphasis on human genetics.
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Registered trials
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