ArticleJournal of gastroenterology1996
Proliferative activity of mixed hyperplastic adenomatous polyp/serrated adenoma in the large intestine, measured by PCNA (proliferating cell nuclear antigen).
Article in Journal of gastroenterology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 20 citations in OpenAlex.
- Proliferation, apoptosis and their regulatory protein expression in colorectal adenomas and serrated lesions.PloS one · 2021Article
- A case of Cronkhite-Canada syndrome presenting with adenomatous and inflammatory colon polyps.Nature reviews. Gastroenterology & hepatology · 2010Review
- Clinico-pathological aspects of colorectal serrated adenomas.World journal of gastroenterology · 2006Article
- Different apoptotic activity and p21(WAF1/CIP1), but not p27(Kip1), expression in serrated adenomas as compared with traditional adenomas and hyperplastic polyps of the colorectum.Journal of cancer research and clinical oncology · 2003Article
- Frequent CpG island methylation in serrated adenomas of the colorectum.The American journal of pathology · 2003Article
- Clinicopathological features of serrated adenoma of the colorectum: comparison with traditional adenoma.Journal of clinical pathology · 1999Article
- Expression of proliferating cell nuclear antigen in polyps from large intestine.World journal of gastroenterology · 1999Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The proliferative activity of serrated adenomas of the large intestine was determined by examining proliferating cell nuclear antigen (PCNA). The PCNA labeling index, determined by visual inspection, and the PCNA area rate, determined with the newly developed image processor for analytical pathology (IPAP), of serrated adenoma were found to be similar to the values for tubular adenoma, and indicated the presence of high proliferative activity in the bottoms of crypts. Determination of the pattern of distribution of PCNA-positive cells indicated the presence of a proliferative zone in the lower region or bottom of the serrated adenoma. However, 5 of the 20 serrated adenomas exhibited an irregular on widely extended proliferative zone, and 2 were complicated by cancer. These findings indicated that serrated adenoma is also a highly proliferative tumor and that it may be complicated by cancer if atypia is increased and disturbance of the proliferative zone is present.
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Registered trials
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