ArticleJournal of virology1996
Epstein-Barr virus nuclear antigen 2 and latent membrane protein independently transactivate p53 through induction of NF-kappaB activity.
Article in Journal of virology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 86 citations in OpenAlex.
- Identification of the immune-related biomarkers in Behcet's disease by plasma proteomic analysis.Arthritis research & therapy · 2023Article
- Epstein-Barr Virus-Positive Lymphoepithelioma-Like Carcinoma in Celiac Disease.ACG case reports journal · 2023Article
- EBV and HPV Infections in Colorectal Cancer and Their Effect on P53 and P16 Protein Expression.International journal of molecular and cellular medicine · 2023Article
- Lymphoepithelioma-like carcinoma of ureter-a rare case report and review of the literature.The Kaohsiung journal of medical sciences · 2012Review
- Article
- Epstein-Barr virus-associated composite lymphoma composed of peripheral T-cell lymphoma and an anaplastic variant of a diffuse large B-cell type of non-Hodgkin's lymphoma and strongly expressing p53 protein.International journal of hematology · 2004Article
- Absence of p53 alterations in nasopharyngeal carcinoma Spanish patients with Epstein-Barr virus infection.Virus genes · 2003Article
- Epstein-Barr virus-associated anaplastic large cell variant of diffuse large B-cell-type non-Hodgkin's lymphoma with concurrent p53 protein expression.International journal of hematology · 2003Article
- Epstein-Barr virus-associated B-cell type non-Hodgkin's lymphoma with concurrent p53 protein expression in a rheumatoid arthritis patient treated with methotrexate.International journal of hematology · 2002Article
- p53 Mutations in nasal natural killer/T-cell lymphoma from Mexico: association with large cell morphology and advanced disease.The American journal of pathology · 2001Article
- Epstein-Barr virus suppresses a G(2)/M checkpoint activated by genotoxins.Molecular and cellular biology · 2000Article
- Epstein-Barr virus-encoded latent membrane protein 1 co-expresses with epidermal growth factor receptor in nasopharyngeal carcinoma.Japanese journal of cancer research : Gann · 1999Article
- Gelatinases A and B are up-regulated in rat lungs by subacute hyperoxia: pathogenetic implications.The American journal of pathology · 1998Article
- The expression of matrix metalloproteinase 9 is enhanced by Epstein-Barr virus latent membrane protein 1.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Epstein-Barr virus binding to CD21 activates the initial viral promoter via NF-kappaB induction.The Journal of experimental medicine · 1997Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
B-cell immortalization by Epstein-Barr virus (EBV) is dependent on permanent control of the cellular processes which normally regulate cell division and apoptosis, functions possessed by p53 in a number of normal cell types. In studies initiated to evaluate relationships between EBV latent genes and p53, p53 levels were found to increase approximately 10-fold 4 to 5 days after EBV infection of purified resting human B cells; the induced p53 was transcriptionally active. Latent membrane protein 1 and, to a lesser extent, EBV nuclear antigen 2 mediated the increase in p53 levels via activation of the NF-kappaB transcription factor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.