ArticleJournal of virology1996
The role of interleukin-10 in the inhibition of T-cell proliferation and apoptosis mediated by parainfluenza virus type 3.
Article in Journal of virology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 35 citations in OpenAlex.
- The Role of Human Parainfluenza Virus Infections in the Immunopathology of the Respiratory Tract.Current allergy and asthma reports · 2017Review
- Complexity and Controversies over the Cytokine Profiles of T Helper Cell Subpopulations in Tuberculosis.Journal of immunology research · 2015Review
- Article
- Aberrant tissue localization of fungus-specific CD4+ T cells in IL-10-deficient mice.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Genome-wide transcriptional response of primary alveolar macrophages following infection with porcine reproductive and respiratory syndrome virus.The Journal of general virology · 2008Article
- Natural killer cells regulate T-cell proliferation during human parainfluenza virus type 3 infection.Journal of virology · 2008Article
- Manipulation of acute inflammatory lung disease.Mucosal immunology · 2008Review
- Alpha and lambda interferon together mediate suppression of CD4 T cells induced by respiratory syncytial virus.Journal of virology · 2006Article
- Lentivirus-mediated gene transfer of viral interleukin-10 delays but does not prevent cardiac allograft rejection.Gene therapy · 2005Article
- Increased production of proinflammatory cytokines following infection with porcine reproductive and respiratory syndrome virus and Mycoplasma hyopneumoniae.Clinical and diagnostic laboratory immunology · 2004Article
- Parainfluenza viruses.Clinical microbiology reviews · 2003Review
- Dendritic cell-derived nitric oxide is involved in IL-4-induced suppression of experimental allergic encephalomyelitis (EAE) in Lewis rats.Clinical and experimental immunology · 1999Article
- Fas ligand deficiency in HIV disease.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously demonstrated that parainfluenza virus type 3 (PIV3), a significant respiratory pathogen, can markedly inhibit T-cell function in vitro. We now report that the virus potently induces interleukin-10 (IL-10) production by peripheral blood mononuclear cells. The IL-10 produced contributes to viral inhibition of T-cell proliferation and protects T cells from PIV3-mediated apoptosis. These findings suggest that IL-10 is likely to play an important immunoregulatory role in PIV3 infections.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.