Evidence map›Paper›PMID 8676519›Full record

ArticleJournal of virology1996

C/EBPbeta is a negative regulator of human papillomavirus type 11 in keratinocytes.

H Wang, K Liu, F Yuan, L Berdichevsky, L B Taichman, K Auborn

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 47 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

H WangDepartment of Otolaryngology, Long Island Jewish Medical Center, Long Island Campus of Albert Einstein College of Medicine, New Hyde Park, New York 11040, USA.
K Liu
F Yuan
L Berdichevsky
L B Taichman
K Auborn
Long Island Jewish Medical Center · US

Funding

STUDIES OF PAPILLOMAS FROM THE UPPER RESPIRATORY TRACTP50DC000203 · NIDCD · LONG ISLAND JEWISH MEDICAL CENTER · PI STEINBERG, BETTIE M. · 1991 to 2004
$5.1M
NIDCD NIH HHS P50 DC00203
6 · The paper itself

Abstract

We have evaluated the impact of the CCAAT enhancer-binding protein (C/EBP) transcription factors on human papillomavirus type 11 (HPV11). C/EBPbeta is in nuclei of cultured foreskin keratinocytes and binds its consensus sequence in HPV11 DNA. We have used the novel approach of depleting the availability of C/EBPs in vivo using nuclease-resistant oligomers containing C/EBP DNA binding sites. In cultured foreskin keratinocytes containing replicating HPV11 DNA, levels of both HPV11 transcripts and HPV DNA increase after treatment with oligomers; containing the C/EBPbeta DNA binding motif. These results indicate that C/EBPbeta is a repressor for HPV11 in keratinocytes.

Indexed as

Base SequenceCCAAT-Enhancer-Binding ProteinsCells, CulturedDNA-Binding ProteinsDNA, ViralHumansKeratinocytesMolecular Sequence DataNuclear ProteinsPapillomaviridaeTranscription, GeneticVirus ReplicationCCAAT-Enhancer-Binding ProteinsDNA-Binding ProteinsDNA, ViralNuclear Proteins

Identifiers

PMID8676519
PMCPMC190429
OpenAlexW1606298359

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.