Is IL-6 both a cytokine and a neurotrophic factor?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

19 citing papers in PubMed.

1. Prolonged Inflammation and Infectious Changes in the Corneal Epithelium Are Associated with Persistent Epithelial Defect (PED).Pathogens (Basel, Switzerland) · 2023
   Article
2. Anti-inflammatory role of GM1 and other gangliosides on microglia.Journal of neuroinflammation · 2022
   Article
3. Mitochondrial Transplantation Attenuates Neural Damage and Improves Locomotor Function After Traumatic Spinal Cord Injury in Rats.Frontiers in neuroscience · 2022
   Article
4. Interleukin-6 promotes microtubule stability in axons via Stat3 protein-protein interactions.iScience · 2021
   Article
5. Intravenously Injected Mesenchymal Stem Cells Penetrate the Brain and Treat Inflammation-Induced Brain Damage and Memory Impairment in Mice.Frontiers in pharmacology · 2019
   Article
6. Implications of altered maternal cytokine concentrations on infant outcomes in children with prenatal alcohol exposure.Alcohol (Fayetteville, N.Y.) · 2018
   Article
7. The Communication Between the Immune and Nervous Systems: The Role of IL-1β in Synaptopathies.Frontiers in molecular neuroscience · 2018
   Review
8. The Influence of Fluorine on the Disturbances of Homeostasis in the Central Nervous System.Biological trace element research · 2017
   Review
9. Interleukin-6 promoter polymorphism interacts with pain and life stress influencing depression phenotypes.Journal of neural transmission (Vienna, Austria : 1996) · 2016
   Article
10. CARFMAP: A Curated Pathway Map of Cardiac Fibroblasts.PloS one · 2015
    Article
11. Maintenance of the enteric stem cell niche by bacterial lipopolysaccharides? Evidence and perspectives.Journal of cellular and molecular medicine · 2014
    Article
12. Role of cytokine signaling during nervous system development.International journal of molecular sciences · 2013
    Review
13. Wingless-type mammary tumor virus integration site family, member 5A (Wnt5a) regulates human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein 120 (gp120)-induced expression of pro-inflammatory cytokines via the Ca2+/calmodulin-dependent protein kinase II (CaMKII) and c-Jun N-terminal kinase (JNK) signaling pathways.The Journal of biological chemistry · 2013
    Article
14. Interleukin-6 gene (IL-6): a possible role in brain morphology in the healthy adult brain.Journal of neuroinflammation · 2012
    Article
15. Interleukin-6 and neural stem cells: more than gliogenesis.Molecular biology of the cell · 2009
    Article
16. Maternal immune activation alters fetal brain development through interleukin-6.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007
    Article
17. Maternal infection and white matter toxicity.Neurotoxicology · 2006
    Review
18. Effects of cytokines and endotoxin on the intracellular growth of bacteria.Infection and immunity · 1999
    Article
19. CNTF and its receptor subunits in human gliomas.Journal of neuro-oncology · 1999
    Article

Corrections and comments

• Comment on
  Accelerated Nerve Regeneration in Mice by upregulated expression of interleukin (IL) 6 and IL-6 receptor after trauma.1996

Authors and funding

1 author.

Funding

Abstract

PubMed holds no abstract for this paper.

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