Bisphosphonates: mechanisms of action.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

218 citing papers in PubMed, 8 syntheses or guidelines pooled it.

1. Prevalence of dental alterations in patients under bisphosphonates therapy: a systematic review.Oral and maxillofacial surgery · 2023
   Pooled it
2. In Vitro Cytotoxicity of Antiresorptive and Antiangiogenic Compounds on Oral Tissues Contributing to MRONJ: Systematic Review.Biomolecules · 2023
   Pooled it
3. Effects of medications on incidence and risk of knee and hip joint replacement in patients with osteoarthritis: a systematic review and meta-analysis.Advances in rheumatology (London, England) · 2022
   Pooled it
4. The effect of sequential therapy for postmenopausal women with osteoporosis: A PRISMA-compliant meta-analysis of randomized controlled trials.Medicine · 2016
   Pooled it
5. The Effect of Teriparatide on Fracture Healing of Osteoporotic Patients: A Meta-Analysis of Randomized Controlled Trials.BioMed research international · 2016
   Pooled it
6. Are bisphosphonates effective in the treatment of osteoarthritis pain? A meta-analysis and systematic review.PloS one · 2013
   Pooled it
7. Adjuvant therapy with zoledronic acid in patients with breast cancer: a systematic review and meta-analysis.The oncologist · 2013
   Pooled it
8. A systematic review of microsurgical reconstruction of the jaws using vascularized fibula flap technique in patients with bisphosphonate-related osteonecrosis.Journal of applied oral science : revista FOB · 2011
   Pooled it
9. Platelet-Rich Fibrin in Surgical Wound Healing of Medication-Related Osteonecrosis of the Jaw: A Pilot Clinical Study.International journal of molecular sciences · 2026
   Trial
10. The effect of denosumab on disseminated tumor cells (DTCs) of breast cancer patients with neoadjuvant treatment: a GeparX translational substudy.Breast cancer research : BCR · 2023
    Trial
11. Does Zoledronic Acid Improve Appendicular Lean Mass in Older Women with Osteoporosis? A Sub-Analysis of a Randomized Clinical Trial.The Journal of frailty & aging · 2022
    Trial
12. Breast cancer outcome in relation to bone mineral density and bisphosphonate use: a sub-study of the DATA trial.Breast cancer research and treatment · 2020
    Trial
13. Comparison of alendronate and raloxifene for the management of primary hyperparathyroidism.Journal of endocrinological investigation · 2013
    Trial
14. Protective effect of myo-inositol hexaphosphate (phytate) on bone mass loss in postmenopausal women.European journal of nutrition · 2013
    Trial
15. Zoledronic acid and clodronate in the treatment of malignant bone metastases with hypercalcaemia; efficacy and safety comparative study.Medical oncology (Northwood, London, England) · 2011
    Trial
16. Efficacy of low doses of pamidronate in osteopenic patients administered in the early post-renal transplant.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2011
    Trial
17. A double-blinded, randomized controlled trial of zoledronate therapy for HIV-associated osteopenia and osteoporosis.AIDS (London, England) · 2009
    Trial
18. Targeting Tumor Stroma: Current Challenges and Future Directions.MedComm · 2026
    Review
19. 24-hour urinary creatinine as a predictor of lumbar spine bone mineral density change after one-year of zoledronic acid treatment in older postmenopausal women with osteoporosis: a cohort study.BMC geriatrics · 2026
    Article
20. Non-union after bisphosphonate-associated atypical femoral fractures: a review of the current literature.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026
    Review

158 more citing papers are in PubMed but not listed here.

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

2 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as