ArticleThe Journal of clinical investigation1995
Inhibition of neointimal proliferation in rabbits after vascular injury by a single treatment with a protein adduct of nitric oxide.
Article in The Journal of clinical investigation, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 228 citations in OpenAlex.
- Nitric oxide in vascular biology: elegance in complexity.The Journal of clinical investigation · 2024Article
- Synthesis and In Vitro Assessment of pH-Sensitive Human Serum Albumin Conjugates of Pirarubicin.Pharmaceuticals (Basel, Switzerland) · 2020Article
- Interplay between Endoplasmic Reticulum Stress and Large Extracellular Vesicles (Microparticles) in Endothelial Cell Dysfunction.Biomedicines · 2020Review
- Attenuation of neointimal formation with netrin-1 and netrin-1 preconditioned endothelial progenitor cells.Journal of molecular medicine (Berlin, Germany) · 2017Article
- Patient-Specific, Multi-Scale Modeling of Neointimal Hyperplasia in Vein Grafts.Frontiers in physiology · 2017Article
- Targeted Nitric Oxide Delivery by Supramolecular Nanofibers for the Prevention of Restenosis After Arterial Injury.Antioxidants & redox signaling · 2016Article
- Oxidative-Nitrosative Stress and Myocardial Dysfunctions in Sepsis: Evidence from the Literature and Postmortem Observations.Mediators of inflammation · 2016Review
- Monitoring vascular permeability and remodeling after endothelial injury in a murine model using a magnetic resonance albumin-binding contrast agent.Circulation. Cardiovascular imaging · 2015Article
- Sex-based differential regulation of oxidative stress in the vasculature by nitric oxide.Redox biology · 2015Article
- Periadventitial atRA citrate-based polyester membranes reduce neointimal hyperplasia and restenosis after carotid injury in rats.American journal of physiology. Heart and circulatory physiology · 2014Article
- Role of metabolic environment on nitric oxide mediated inhibition of neointimal hyperplasia in type 1 and type 2 diabetes.Nitric oxide : biology and chemistry · 2014Article
- The cGMP signaling pathway as a therapeutic target in heart failure with preserved ejection fraction.Journal of the American Heart Association · 2013Review
- Nitric oxide delivery via a permeable balloon catheter inhibits neointimal growth after arterial injury.The Journal of surgical research · 2013Article
- Vascular aging: chronic oxidative stress and impairment of redox signaling-consequences for vascular homeostasis and disease.Annals of medicine · 2013Review
- S-nitrosothiols and the S-nitrosoproteome of the cardiovascular system.Antioxidants & redox signaling · 2013Review
- Poly-s-nitrosated albumin as a safe and effective multifunctional antitumor agent: characterization, biochemistry and possible future therapeutic applications.BioMed research international · 2013Review
- Superoxide dismutase as a novel macromolecular nitric oxide carrier: preparation and characterization.International journal of molecular sciences · 2012Article
- The role of estrogen receptor α and β in regulating vascular smooth muscle cell proliferation is based on sex.The Journal of surgical research · 2012Article
- Endothelial dysfunction and diabetes: effects on angiogenesis, vascular remodeling, and wound healing.International journal of vascular medicine · 2012Article
- Mathematical and computational models of oxidative and nitrosative stress.Critical reviews in biomedical engineering · 2011Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Endothelium-derived relaxing factor is important for vascular homeostasis and possesses qualities that may modulate vascular injury, including vasodilation, platelet inhibition, and inhibition of smooth muscle proliferation. S-nitrososerum albumin is a naturally occurring adduct of nitric oxide (NO) with a prolonged biologic half-life and is a potent vasodilator and platelet inhibitor. Given the avidity of serum albumin for subendothelial matrix and the antiproliferative effects of NO, we investigated the effects of locally delivered S-nitroso-bovine serum albumin (S-NO-BSA) and a polythiolated form of bovine serum albumin (pS-BSA) modified to carry several S-nitrosothiol groups (pS-NO-BSA) on neointimal responses in an animal model of vascular injury. Locally delivered S-NO-BSA bound preferentially to denuded rabbit femoral vessels producing a 26-fold increase in local concentration compared with uninjured vessels (P = 0.029). pS-NO-BSA significantly reduced the intimal/medial ratio (P = 0.038) and did so in conjunction with elevations in platelet (P < 0.001) and vascular cGMP content (P < or = 0.001). pS-NO-BSA treatment also inhibited platelet deposition (P = 0.031) after denuding injury. Comparison of BSA, S-NO-BSA, pS-NO-BSA, and control revealed a dose-response relationship between the amount of displaceable NO delivered and the extent of inhibition of neointimal proliferation at 2 wk (P < or = 0.001). Local administration of a stable protein S-nitrosothiol inhibits intimal proliferation and platelet deposition after vascular arterial balloon injury. This strategy for the local delivery of a long-lived NO adduct has potential for preventing restenosis after angioplasty.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.