ArticleGut1996
Why is epidermal growth factor present in the gut lumen?
Article in Gut, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 106 citations in OpenAlex.
- Effects of epidermal growth factor on atrophic enteritis in piglets induced by experimental porcine epidemic diarrhoea virus.Veterinary journal (London, England : 1997) · 2008Trial
- Epidermal Growth Factor Intralesional Delivery in Chronic Wounds: The Pioneer and Standalone Technique for Reversing Wound Chronicity and Promoting Sustainable Healing.International journal of molecular sciences · 2024Review
- Physiological effects ofFrontiers in veterinary science · 2023Review
- Immunohistochemical Studies of Age-Related Changes in Cell Proliferation and Angiogenesis during the Healing of Acetic Acid-Induced Gastric Ulcers in Rats.TheScientificWorldJournal · 2020Article
- The relation between serum levels of epidermal growth factor and necrotizing enterocolitis in preterm neonates.Korean journal of pediatrics · 2019Article
- Distribution of bioactive factors in human milk samples.International breastfeeding journal · 2019Article
- Crystal structure and mechanism of human carboxypeptidase O: Insights into its specific activity for acidic residues.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- ADAM proteases involved in inflammation are differentially altered in patients with gastritis or ulcer.Experimental and therapeutic medicine · 2018Article
- Protective effects of amniotic fluid in the setting of necrotizing enterocolitis.Pediatric research · 2017Review
- Growth performance and gastrointestinal responses of broiler chickens fed corn-soybean meal diet without or with exogenous epidermal growth factor upon challenge with Eimeria.Poultry science · 2017Article
- Low day +100 serum epidermal growth factor levels are associated with acute GvHD after allogeneic hematopoietic cell transplantation.Bone marrow transplantation · 2017Article
- Epidermal growth factor suppresses intestinal epithelial cell shedding through a MAPK-dependent pathway.Journal of cell science · 2017Article
- Sieving characteristics of cytokine- and peroxide-induced epithelial barrier leak: Inhibition by berberine.World journal of gastrointestinal pathophysiology · 2016Article
- Amniotic fluid: Source of trophic factors for the developing intestine.World journal of gastrointestinal pathophysiology · 2016Review
- Pathogenesis of neonatal necrotizing enterocolitis.Pediatric surgery international · 2015Review
- Proton pump inhibitors are not the key for therapying non-steroidal anti-inflammatory drugs-induced small intestinal injury.Rheumatology international · 2013Article
- The role of growth factors in intestinal regeneration and repair in necrotizing enterocolitis.Seminars in pediatric surgery · 2013Review
- Epidermal growth factor receptor expression and signaling are essential in glutamine's cytoprotective mechanism in heat-stressed intestinal epithelial-6 cells.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
- Epidermal growth factor chronically upregulates Ca(2+)-dependent Cl(-) conductance and TMEM16A expression in intestinal epithelial cells.The Journal of physiology · 2012Article
- Gastric juice prostaglandins and peptide growth factors as potential markers of chronic atrophic gastritis, intestinal metaplasia and gastric cancer: their potential clinical implications based on this pilot study.Digestive diseases and sciences · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The jury is still out on the role of luminal EGF in the normal gastrointestinal tract. Recent evidence, however, suggests that its major function is to act as a 'luminal surveillance' peptide, which is available to stimulate repair and that it is not of major importance in maintaining normal gut growth. Recombinant EGF administered via the gut lumen could still prove a valuable tool for the treatment of gastrointestinal ulceration. Perhaps the old term for EGF, 'epidermal healing factor' or EHF, was more appropriate after all!
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.