ArticleMammalian genome : official journal of the International Mammalian Genome Society1996
Mapping of two genetic loci, Ten-1 and Ten-2, associated with thymus enlargement in BUF/Mna rats.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 citing papers in PubMed, 16 citations in OpenAlex.
- Cervical thymuses exist, but no cervical thymomas develop in thoracic thymoma-prone BUF rats.International journal of experimental pathology · 2011Article
- Establishment of thymoma-prone congenic rat strain, ACI.BUF/Mna-Tsr1/Tsr1.Journal of cancer research and clinical oncology · 2008Article
- Genetic models: clues for understanding the pathogenesis of idiopathic nephrotic syndrome.The Journal of clinical investigation · 2002Review
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7 authors at 5 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The thymoma-prone BUF/Mna rat is a useful model for human thymoma. Thymoma develops spontaneously in these rats at an incidence of nearly 100%. At pre-thymoma age, BUF/Mna rats have extremely large thymuses when compared with those of rats of the other strains, suggesting the presence of genes that regulate the thymus enlargement. We performed linkage study to identify the genetic loci associated with thymus enlargement in {(WKY/NCrj x BUF/Mna) F1 x BUF/Mna} backcross rats. Linkage study showed the significant associations between thymus size and markers on Chromosomes (Chrs) 1 and 13, suggesting the presence of two genes, Ten-1 and Ten-2, which regulate the thymus enlargement. Ten-1 was located between myosin light chain, muscle 2 (MYL2) and D1Mgh11 loci on Chr 1, and Ten-2 was located between synaptotagmin II (SYT2) and D13N2 loci on Chr 13.
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