ArticleThe EMBO journal1996
A novel role for the budding yeast RAD9 checkpoint gene in DNA damage-dependent transcription.
Article in The EMBO journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
53 citing papers in PubMed, 109 citations in OpenAlex.
- Fun30 and Rtt109 Mediate Epigenetic Regulation of the DNA Damage Response Pathway inJournal of fungi (Basel, Switzerland) · 2022Article
- Distinct associations of the Saccharomyces cerevisiae Rad9 protein link Mac1-regulated transcription to DNA repair.Current genetics · 2020Article
- Mutations in the Non-Catalytic Subunit Dpb2 of DNA Polymerase Epsilon Affect the Nrm1 Branch of the DNA Replication Checkpoint.PLoS genetics · 2017Article
- Inviability of a DNA2 deletion mutant is due to the DNA damage checkpoint.Cell cycle (Georgetown, Tex.) · 2011Article
- A role for checkpoint kinase-dependent Rad26 phosphorylation in transcription-coupled DNA repair in Saccharomyces cerevisiae.Molecular and cellular biology · 2010Article
- Ribonucleotide reductase regulation in response to genotoxic stress in Arabidopsis.Plant physiology · 2009Article
- RAD50 is required for efficient initiation of resection and recombinational repair at random, gamma-induced double-strand break ends.PLoS genetics · 2009Article
- UV but not X rays stimulate homologous recombination between sister chromatids and homologs in a Saccharomyces cerevisiae mec1 (ATR) hypomorphic mutant.Mutation research · 2008Article
- Article
- Break dosage, cell cycle stage and DNA replication influence DNA double strand break response.The EMBO journal · 2008Article
- Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage.Molecular cell · 2008Article
- Regulation of Saccharomyces cerevisiae DNA polymerase eta transcript and protein.Radiation and environmental biophysics · 2008Article
- Role of Doa1 in the Saccharomyces cerevisiae DNA damage response.Molecular and cellular biology · 2006Article
- The budding yeast protein Chl1p is required to preserve genome integrity upon DNA damage in S-phase.Nucleic acids research · 2006Article
- Expression of a human cytochrome p450 in yeast permits analysis of pathways for response to and repair of aflatoxin-induced DNA damage.Molecular and cellular biology · 2005Article
- Boundaries and physical characterization of a new domain shared between mammalian 53BP1 and yeast Rad9 checkpoint proteins.Protein science : a publication of the Protein Society · 2005Article
- Homologous recombination is involved in transcription-coupled repair of UV damage in Saccharomyces cerevisiae.The EMBO journal · 2005Article
- Cell cycle progression in G1 and S phases is CCR4 dependent following ionizing radiation or replication stress in Saccharomyces cerevisiae.Eukaryotic cell · 2004Article
- Enhanced stimulation of chromosomal translocations by radiomimetic DNA damaging agents and camptothecin in Saccharomyces cerevisiae rad9 checkpoint mutants.Mutation research · 2004Article
- Global gene expression responses of fission yeast to ionizing radiation.Molecular biology of the cell · 2004Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cells respond to DNA damage by arresting cell cycle progression and activating several DNA repair mechanisms. These responses allow damaged DNA to be repaired efficiently, thus ensuring the maintenance of genetic integrity. In the budding yeast, Saccharomyces cerevisiae, DNA damage leads both to activation of checkpoints at the G1, S and G2 phases of the cell cycle and to a transcriptional response. The G1 and G2 checkpoints have been shown previously to be under the control of the RAD9 gene. We show here that RAD9 is also required for the transcriptional response to DNA damage. Northern blot analysis demonstrated that RAD9 controls the DNA damage-specific induction of a large 'regulon' of repair, replication and recombination genes. This induction is cell-cycle independent as it was observed in asynchronous cultures and cells blocked in G1 or G2/M. RAD9-dependent induction was also observed from isolated damage responsive promoter elements in a lacZ reporter-based plasmid assay. RAD9 cells deficient in the transcriptional response were more sensitive to DNA damage than wild-type cells, even after functional substitution of checkpoints, suggesting that this activation may have an important role in DNA repair. Our findings parallel observations with the Escherichia coli SOS system and suggest the existence of an analogous eukaryotic network coordinating the cellular responses to DNA damage.
Indexed as
Identifiers
8670896PMC452098W2286330464What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.