ArticleThe EMBO journal1996
The hybrid histidine kinase DokA is part of the osmotic response system of Dictyostelium.
Article in The EMBO journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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Who cites it
46 citing papers in PubMed, 139 citations in OpenAlex.
- Correlation of CheY-P concentration and motor behavior during attractant adaptation in singleScience advances · 2026Article
- CheB localizes to polar receptor arrays during repellent adaptation.Science advances · 2024Article
- Plant Salinity Sensors: Current Understanding and Future Directions.Frontiers in plant science · 2022Review
- The Journey from Two-Step to Multi-Step Phosphorelay Signaling Systems.Current genomics · 2021Review
- What do archaeal and eukaryotic histidine kinases sense?F1000Research · 2019Review
- Evolution of developmental signalling in Dictyostelid social amoebas.Current opinion in genetics & development · 2016Review
- Major Sensing Proteins in Pathogenic Fungi: The Hybrid Histidine Kinase Family.PLoS pathogens · 2016Review
- The multicellularity genes of dictyostelid social amoebas.Nature communications · 2016Article
- The Evolution of Aggregative Multicellularity and Cell-Cell Communication in the Dictyostelia.Journal of molecular biology · 2015Review
- The cyclic AMP phosphodiesterase RegA critically regulates encystation in social and pathogenic amoebas.Cellular signalling · 2014Article
- The arrestin-domain containing protein AdcA is a response element to stress.Cell communication and signaling : CCS · 2013Article
- Loss of the histidine kinase DhkD results in mobile mounds during development of Dictyostelium discoideum.PloS one · 2013Article
- Coordinated regulation of multiple flagellar motors by theBiophysics (Nagoya-shi, Japan) · 2012Review
- Solute-dependent activation of cell motility in strongly hypertonic solutions in Dictyostelium discoideum, human melanoma HTB-140 cells and walker 256 carcinosarcoma cells.Cellular & molecular biology letters · 2011Article
- Bio-electrospraying and aerodynamically assisted bio-jetting the model eukaryotic Dictyostelium discoideum: assessing stress and developmental competency post treatment.Journal of the Royal Society, Interface · 2011Article
- Coordinated reversal of flagellar motors on a single Escherichia coli cell.Biophysical journal · 2011Article
- Autophagic cell death in Dictyostelium requires the receptor histidine kinase DhkM.Molecular biology of the cell · 2010Article
- Article
- Adenylyl cyclase G is activated by an intramolecular osmosensor.Molecular biology of the cell · 2004Article
- Loss of the F-actin binding and vesicle-associated protein comitin leads to a phagocytosis defect.Eukaryotic cell · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have used PCR to identify a Dictyostelium homolog of the bacterial two-component system. The gene dokA codes for a member of the hybrid histidine kinase family which is defined by the presence of conserved amino acid sequence motifs corresponding to an N-terminal receptor domain, a central kinase and a C-terminal response regulator moiety. Potential function of the regulator domain was demonstrated by phosphorylation in vitro. dokA mutants are deficient in the osmoregulatory pathway, resulting in premature cell death under high osmotic stress. Under less stringent osmotic conditions, cells grow at a normal rate, but development at the multicellular stage is altered. dokA is a member of a family of histidine kinase-like genes that play regulatory roles in eukaryotic cell function.
Indexed as
Identifiers
8670893PMC452086W1837503093What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.