ArticleThe EMBO journal1996
Ca2+ triggers massive exocytosis in Chinese hamster ovary cells.
Article in The EMBO journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
58 citing papers in PubMed.
- One Year of Enzyme Replacement Therapy Reduces Globotriaosylceramide Inclusions in Podocytes in Male Adult Patients with Fabry Disease.PloS one · 2016Trial
- Induction of lysosomal exocytosis and biogenesis via TRPML1 activation for the treatment of uranium-induced nephrotoxicity.Nature communications · 2023Article
- A Compendium of Information on the Lysosome.Frontiers in cell and developmental biology · 2021Review
- Article
- The neuroendocrine phenotype of gastric myofibroblasts and its loss with cancer progression.Carcinogenesis · 2014Article
- Lysosomal exocytosis and lipid storage disorders.Journal of lipid research · 2014Review
- Exocytosis and endocytosis: modes, functions, and coupling mechanisms.Annual review of physiology · 2014Review
- High-resolution membrane capacitance measurements for the study of exocytosis and endocytosis.Nature protocols · 2013Article
- Signals from the lysosome: a control centre for cellular clearance and energy metabolism.Nature reviews. Molecular cell biology · 2013Review
- Enhanced recruitment of endosomal Na+/H+ exchanger NHE6 into Dendritic spines of hippocampal pyramidal neurons during NMDA receptor-dependent long-term potentiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Host cell invasion by Trypanosoma cruzi: a unique strategy that promotes persistence.FEMS microbiology reviews · 2012Review
- Vesicular calcium channels as regulators of the exocytotic post-fusion phase.Communicative & integrative biology · 2011Article
- Restricted lateral diffusion of luteinizing hormone receptors in membrane microdomains.The Journal of biological chemistry · 2011Article
- Understanding synapses: past, present, and future.Neuron · 2008Article
- Two-way traffic on the road to plasma membrane repair.Trends in cell biology · 2008Review
- Lysosomes are the major vesicular compartment undergoing Ca2+-regulated exocytosis from cortical astrocytes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Massive Ca-induced membrane fusion and phospholipid changes triggered by reverse Na/Ca exchange in BHK fibroblasts.The Journal of general physiology · 2008Article
- Fusion gains independence.The Journal of general physiology · 2008Article
- Ca-dependent nonsecretory vesicle fusion in a secretory cell.The Journal of general physiology · 2008Article
- Resolving vesicle fusion from lysis to monitor calcium-triggered lysosomal exocytosis in astrocytes.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have tracked the cell surface area of CHO cells by measuring the membrane capacitance, Cm. An increase in cytosolic [Ca2+], [Ca2+]i, increased the cell surface area by 20-30%. At micromolar [Ca2+]i the increase occurred in minutes, while at 20 microM or higher [Ca2+]i it occurred in seconds and was transient. GTPgammaS caused a 3% increase even at 0.1 microM [Ca2+]i. We conclude that CHO cells, previously thought capable only of constitutive exocytosis, can perform Ca2+-triggered exocytosis that is both massive and rapid. Ca2+-triggered exocytosis was also observed in 3T3 fibroblasts. Our findings add evidence to the view that Ca induces exocytosis in cells other than known secretory cells.
Indexed as
Identifiers
8670883PMC452059What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.