ArticleThe EMBO journal1996
Newly assembled cyclin B-cdc2 kinase is required to suppress DNA replication between meiosis I and meiosis II in starfish oocytes.
Article in The EMBO journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 73 citations in OpenAlex.
- Dissection of the Ovulatory Process UsingFrontiers in cell and developmental biology · 2020Review
- Review
- Keeping a good rep in meiosis: mind the CDK.Cell cycle (Georgetown, Tex.) · 2009Article
- Progression through meiosis I and meiosis II in Arabidopsis anthers is regulated by an A-type cyclin predominately expressed in prophase I.Plant physiology · 2004Article
- Article
- Induction of apoptosis in starfish eggs requires spontaneous inactivation of MAPK (extracellular signal-regulated kinase) followed by activation of p38MAPK.Molecular biology of the cell · 2004Article
- Distinct regulators for Plk1 activation in starfish meiotic and early embryonic cycles.The EMBO journal · 2003Article
- The G1/S cyclin Cig2p during meiosis in fission yeast.Molecular biology of the cell · 2002Article
- Cyclin B/cdc2 induces c-Mos stability by direct phosphorylation in Xenopus oocytes.Molecular biology of the cell · 2001Article
- c-Mos forces the mitotic cell cycle to undergo meiosis II to produce haploid gametes.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- DNA replication and damage checkpoints and meiotic cell cycle controls in the fission and budding yeasts.The Biochemical journal · 2000Review
- Hsp90 is required for c-Mos activation and biphasic MAP kinase activation in Xenopus oocytes.The EMBO journal · 2000Article
- Absence of Wee1 ensures the meiotic cell cycle in Xenopus oocytes.Genes & development · 2000Article
- Regulation of the G1 phase of the cell cycle by periodic stabilization and degradation of the p25rum1 CDK inhibitor.The EMBO journal · 1998Article
- MAPK inactivation is required for the G2 to M-phase transition of the first mitotic cell cycle.The EMBO journal · 1997Article
- MAP kinase links the fertilization signal transduction pathway to the G1/S-phase transition in starfish eggs.The EMBO journal · 1997Article
- Mitogen-activated protein kinase activation down-regulates a mechanism that inactivates cyclin B-cdc2 kinase in G2-arrested oocytes.Molecular biology of the cell · 1997Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Micro-injection of catalytically inactive GST-cdc2-K33R or GST-cdk2-K33R fusion proteins, each of which efficiently titrates cyclin B in oocytes and prevents assembly of cyclin B-cdc2 complexes, readily induces premature DNA replication in starfish oocytes after emission of the first polar body. Moreover, partial ablation of cyclin B mRNA by micro-injection of antisense oligonucleotides facilitates premature DNA replication induced by the dominant-negative cdc2 and cdk2 mutant proteins. We thus propose that enhanced translation of cyclin B after GVBD, a universal feature of oocyte maturation in the animal kingdom, and subsequent assembly of cyclin B-cdc2 complexes, are part of the checkpoint that prevents DNA replication in the oocyte after emission of the first polar body. MAPK inactivation is neither required for premature DNA replication after the first meiotic cell cycle nor for DNA replication after completion of meiotic maturation. However, micro-injection of a N-terminally truncated form of the budding yeast STE11 protein, that constitutively maintains MAPK active after the second meiotic cleavage, prevents fertilized eggs from proceeding into embryogenesis, and arrests them at G2, as is the case in unfertilized eggs that cannot inactivate MAPK after the second meiotic cleavage. We thus propose that MAPK functions in meiotic maturation by preventing unfertilized eggs from proceeding into parthenogenetic development.
Indexed as
Identifiers
8670862PMC451967W271731697What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.