ArticleThe EMBO journal1996
Control of expression of the I factor, a LINE-like transposable element in Drosophila melanogaster.
Article in The EMBO journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Involvement of DNA Repair Genes and System of Radiation-Induced Activation of Transposons in Formation of Transgenerational Effects.Frontiers in genetics · 2020Article
- High-fidelity promoter profiling reveals widespread alternative promoter usage and transposon-driven developmental gene expression.Genome research · 2013Article
- Molecular dissection of Penelope transposable element regulatory machinery.Nucleic acids research · 2008Article
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- Copy number control of a transposable element, the I factor, a LINE-like element in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Evidence for a multistep control in transposition of I factor in Drosophila melanogaster.Genetics · 1998Article
- A genetically marked I element in Drosophila melanogaster can be mobilized when ORF2 is provided in trans.Genetics · 1998Article
- A LINE-like transposable element in Drosophila, the I factor, encodes a protein with properties similar to those of retroviral nucleocapsids.The EMBO journal · 1997Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
I factors are LINE-like transposable elements in the genome of Drosophila melanogaster. They normally transpose infrequently but are activated in the germline of female progeny of crosses between males of a strain that contains complete elements, an I or inducer strain and females of a strain that does not, an R or reactive strain. This causes a phenomenon known as I-R hybrid dysgenesis. We have previously shown that the I factor promoter lies between nucleotides 1 and 30. Here we demonstrate that expression of this promoter is regulated by nucleotides 41-186 of the I factor. This sequence can act as an enhancer as it stimulates expression of the hsp7O promoter in ovaries in the absence of heat-shock. Within this region there is a site that is required for promoter activity and that is recognized by a sequence-specific binding protein. We propose that this protein contributes to the enhancer activity of nucleotides 41-186 and that reduced I factor expression in inducer strains is due to titration of this protein or others that interact with it.
Indexed as
Identifiers
8670818PMC450260What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.