ArticleThe EMBO journal1996
Human TAF(II28) promotes transcriptional stimulation by activation function 2 of the retinoid X receptors.
Article in The EMBO journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 83 citations in OpenAlex.
- Role of Nuclear Receptors in Central Nervous System Development and Associated Diseases.Journal of experimental neuroscience · 2015Review
- Distinct regulatory mechanisms of eukaryotic transcriptional activation by SAGA and TFIID.Biochimica et biophysica acta · 2011Review
- Differential regulation of the glucose-6-phosphatase TATA box by intestine-specific homeodomain proteins CDX1 and CDX2.Nucleic acids research · 2003Article
- Distinct mutations in yeast TAF(II)25 differentially affect the composition of TFIID and SAGA complexes as well as global gene expression patterns.Molecular and cellular biology · 2002Article
- The S. cerevisiae SAGA complex functions in vivo as a coactivator for transcriptional activation by Gal4.Genes & development · 2001Article
- Recruitment of an RNA polymerase II complex is mediated by the constitutive activation domain in CREB, independently of CREB phosphorylation.Molecular and cellular biology · 2001Article
- Prodos is a conserved transcriptional regulator that interacts with dTAF(II)16 in Drosophila melanogaster.Molecular and cellular biology · 2001Article
- The human TFIID components TAF(II)135 and TAF(II)20 and the yeast SAGA components ADA1 and TAF(II)68 heterodimerize to form histone-like pairs.Molecular and cellular biology · 2000Article
- Human TAF(II)55 interacts with the vitamin D(3) and thyroid hormone receptors and with derivatives of the retinoid X receptor that have altered transactivation properties.Molecular and cellular biology · 1999Article
- Synergistic transcriptional activation by TATA-binding protein and hTAFII28 requires specific amino acids of the hTAFII28 histone fold.Molecular and cellular biology · 1999Article
- Thyroid hormone receptor-associated proteins and general positive cofactors mediate thyroid hormone receptor function in the absence of the TATA box-binding protein-associated factors of TFIID.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Selective interaction of vitamin D receptor with transcriptional coactivators by a vitamin D analog.Molecular and cellular biology · 1999Article
- Transcription of the juvenile hormone esterase gene under the control of both an initiator and AT-rich motif.The Biochemical journal · 1998Article
- TAFII105 mediates activation of anti-apoptotic genes by NF-kappaB.The EMBO journal · 1998Article
- TAFII-independent activation mediated by human TBP in the presence of the positive cofactor PC4.The EMBO journal · 1998Article
- A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system.Genes & development · 1998Article
- p300 and estrogen receptor cooperatively activate transcription via differential enhancement of initiation and reinitiation.Genes & development · 1998Article
- The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways.The EMBO journal · 1998Article
- A multiplicity of mediators: alternative forms of transcription complexes communicate with transcriptional regulators.Nucleic acids research · 1997Review
- The transactivation domain of adenovirus E1A interacts with the C terminus of human TAF(II)135.Journal of virology · 1997Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcriptional activation in vitro involves direct interactions of transactivators with the TATA binding protein (TBP) and the TBP-associated factors (TAF(II)s) which constitute the TFIID complex. However, the role of TAF(II)s in transcriptional regulation in mammalian cells has not been addressed. We show that activation function 2 of the retinoid X receptors (RXR AF-2) does not activate transcription from a minimal promoter in Cos cells. However, coexpression of human (h) TAF(II)28 promotes a strong ligand-dependent activity of the RXR AF-2 on a minimal promoter and potentiates the ability of the RXRalpha AF-2 to activate transcription from a complex promoter. The expression of hTAF(II)28 also potentiated transactivation by several nuclear receptors, notably the oestrogen and vitamin D3 receptors (ER and VDR), whereas other classes of activator were not affected. The effect of hTAFII(28) on RXR AF-2 activities did not appear to require direct RXR-TAFII(28) interactions, but correlated with the ability of hTAFII(28) to interact with TBP. In contrast to Cos cells, the RXR AF-2s had differential abilities to activate transcription from a minimal promoter in HeLa cells, and a lesser increase in their activity was observed upon hTAFII28 coexpression. Moreover, coexpression of hTAFII(28) did not increase but rather repressed activation by the ER and VDR AF-2s in HeLa cells. In agreement with these data, showing that TAF(II)28 is limiting in the AF-2 activation pathway in Cos cells, TAF(II)28 is selectively depleted in Cos cell TFIID.
Indexed as
Identifiers
8670810PMC450252W140469120What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.