ArticleThe EMBO journal1996
The 'destruction box' of cyclin A allows B-type cyclins to be ubiquitinated, but not efficiently destroyed.
Article in The EMBO journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 74 citations in OpenAlex.
- Cyclin A2 degradation during the spindle assembly checkpoint requires multiple binding modes to the APC/C.Nature communications · 2019Article
- Building a Regulatory Network with Short Linear Sequence Motifs: Lessons from the Degrons of the Anaphase-Promoting Complex.Molecular cell · 2016Review
- APOLLON protein promotes early mitotic CYCLIN A degradation independent of the spindle assembly checkpoint.The Journal of biological chemistry · 2014Article
- Histone deacetylase 3 regulates cyclin A stability.The Journal of biological chemistry · 2013Article
- A brief history of error.Nature cell biology · 2011Article
- Defining the geometry of the two-component proteasome degron.Nature chemical biology · 2011Article
- Targeting proteins for degradation.Nature chemical biology · 2009Review
- Degradation of cyclin A is regulated by acetylation.Oncogene · 2009Article
- Substrate selection by the proteasome during degradation of protein complexes.Nature chemical biology · 2009Article
- Ku80 removal from DNA through double strand break-induced ubiquitylation.The Journal of cell biology · 2008Article
- Article
- RFPL4 interacts with oocyte proteins of the ubiquitin-proteasome degradation pathway.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Collapsin response mediator protein-1: a novel invasion-suppressor gene.Clinical & experimental metastasis · 2003Review
- Timing of APC/C substrate degradation is determined by fzy/fzr specificity of destruction boxes.The EMBO journal · 2002Article
- A complex degradation signal in Cyclin A required for G1 arrest, and a C-terminal region for mitosis.The EMBO journal · 2001Article
- Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint.The Journal of cell biology · 2001Article
- Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase.The Journal of cell biology · 2001Article
- Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis.The EMBO journal · 2001Article
- The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1.Genes & development · 2000Article
- Cell cycle -dependent proteolysis in plants. Identification Of the destruction box pathway and metaphase arrest produced by the proteasome inhibitor mg132The Plant cell · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The destruction of mitotic cyclins by programmed proteolysis at the end of mitosis is an important element in cell cycle control. This proteolysis depends on a conserved motif of nine residues known as the 'destruction box', which is located 40-50 residues from the N-terminus. The sequences of the A- and B-type destruction boxes are slightly different, which might account for the differences in timing of their destruction. When the cyclin A-type destruction box was substituted for the normal one in cyclin B1 or B2, however, the resulting constructs were unexpectedly stable, although the converse substitution of B-type destruction boxes in cyclin A permitted normal degradation. We compared the ubiquitination of various cyclin constructs, and found that whereas mutation of the highly conserved residues in the destruction box strongly reduced the level of ubiquitinated intermediates, the stable destruction box 'swap' constructs did form such adducts. Thus, while ubiquitination is probably necessary for cyclin destruction, it is not sufficient. We also found that poly-ubiquitinated cyclin derivatives are still bound to p34cdc2, which is not detectably ubiquitinated itself, raising the questions of how cyclin and cdc2 dissociate from one another, and at what stage, in the process of degradation.
Indexed as
Identifiers
8670806PMC450246W1959249887What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.