ArticleThe Biochemical journal1996
The ability of POU family transcription factors to activate or repress gene expression is dependent on the spacing and context of their specific response elements.
Article in The Biochemical journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Disease related changes in ATAC-seq of iPSC-derived motor neuron lines from ALS patients and controls.Nature communications · 2024Article
- Bipartite recognition of DNA by TCF/Pangolin is remarkably flexible and contributes to transcriptional responsiveness and tissue specificity of wingless signaling.PLoS genetics · 2014Article
- Caprin-1 is a target of the deafness gene Pou4f3 and is recruited to stress granules in cochlear hair cells in response to ototoxic damage.Journal of cell science · 2011Article
- Discovering modulators of gene expression.Nucleic acids research · 2010Article
- Coordinate regulation of gene expression in the C. elegans excretory cell by the POU domain protein CEH-6.Molecular genetics and genomics : MGG · 2010Article
- Cloning and initial characterization of an alternatively spliced transcript encoded by the bovine herpes virus 1 latency-related gene.Journal of neurovirology · 2003Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The different forms of the Oct-2 and Brn-3 POU family transcription factors can have distinct effects on their target promoters involving both the activation and repression of gene expression. To investigate the requirements for these effects we have altered both the context and spacing of the two TAATGARAT binding sites for these factors within the herpes simplex virus immediate-early 3 gene promoter. We show that the activation of this promoter by Brn-3a and its repression by Brn-3b is dependent on the correct spacing of these binding sites. In contrast, repression of the promoter by Oct-2.4 and Oct-2.5 is dependent on both the spacing and context of these sites with the requirements for repression by Oct-2.4 or Oct-2.5 being different. These effects are discussed in the context of the mechanisms by which POU factors activate or repress their target genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.