Evidence map›Paper›PMID 8670047›Full record

ArticleThe Biochemical journal1996

Activation of a protein tyrosine phosphatase and inactivation of Raf-1 by somatostatin.

D B Reardon, S L Wood, D L Brautigan, G I Bell, P Dent, T W Sturgill

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Biochemical journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 49 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. SST3-selective potent peptidic somatostatin receptor antagonists.Proceedings of the National Academy of Sciences of the United States of America · 2000
    Article
  7. Molecular pharmacology of somatostatin receptor subtypes.Journal of endocrinological investigation · 1997
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

D B ReardonHoward Hughes Medical Institute, University of Virginia, Charlottesville, VA 22908, U.S.A.
S L Wood
D L Brautigan
G I Bell
P Dent
T W Sturgill
Howard Hughes Medical Institute · USUniversity of Virginia · US

Funding

RESEARCH TRAINING IN DIABETES AND HORMONES ACTIONT32DK007320 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI BARRETT, EUGENE JOSEPH · 1986 to 2012
$2.4M
REGULATION AND FUNCTION OF INSULIN-STIMULATED MAP KINASER01DK041077 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI STURGILL, THOMAS W · 1989 to 1998
–
HEMATOLOGY/ONCOLOGYT32DK007509 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI MYERS, CHARLES R · 1986 to 1995
–
NIDDK NIH HHS DK07320NIDDK NIH HHS DK07509NIDDK NIH HHS DK41077
6 · The paper itself

Abstract

Human somatostatin receptor 3 ('hsstr3') was transiently expressed in NIH 3T3 cells stably transformed with Ha-Ras (G12V). Somatostatin activated a protein tyrosine phosphatase and inactivated the constitutively active, membrane-associated form of the Raf-1 serine kinase present in these cells in vivo and in vitro.

Indexed as

3T3 CellsAnimalsCell Line, TransformedEnzyme ActivationGenes, rasMiceProtein BindingProtein Serine-Threonine KinasesProtein Tyrosine PhosphatasesProto-Oncogene ProteinsProto-Oncogene Proteins c-rafSomatostatinProtein Serine-Threonine KinasesProtein Tyrosine PhosphatasesProto-Oncogene ProteinsProto-Oncogene Proteins c-rafSomatostatin

Identifiers

PMID8670047
PMCPMC1217062
OpenAlexW2218224144

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.