ArticleThe American journal of pathology1996
Immunolocalization and gene expression of oxytocin receptors in carcinomas and non-neoplastic tissues of the breast.
Article in The American journal of pathology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 65 citations in OpenAlex.
- Differences of immunoreactivity for luminal and myoepithelial cell markers and oxytocin receptor in canine normal mammary ducts and ductal tumors.The Journal of veterinary medical science · 2026Article
- Targeting the Oxytocin Receptor for Breast Cancer Management: A Niche for Peptide Tracers.Journal of medicinal chemistry · 2024Review
- High Oxytocin Receptor Expression Linked to Increased Cell Migration and Reduced Survival in Patients with Triple-Negative Breast Cancer.Biomedicines · 2022Article
- Oxytocin receptor induces mammary tumorigenesis through prolactin/p-STAT5 pathway.Cell death & disease · 2021Article
- Review
- RNAi Screening-based Identification of USP10 as a Novel Regulator of Paraptosis.Scientific reports · 2019Article
- Breast cancer and social environment: getting by with a little help from our friends.Breast cancer research : BCR · 2016Review
- The pro-social neurohormone oxytocin reverses the actions of the stress hormone cortisol in human ovarian carcinoma cells in vitro.International journal of oncology · 2016Article
- Antiproliferative Effects of Oxytocin and Desmopressin on Canine Mammary Cancer Cells.Frontiers in veterinary science · 2016Article
- Regulator of G-protein signalling 2 mRNA is differentially expressed in mammary epithelial subpopulations and over-expressed in the majority of breast cancers.Breast cancer research : BCR · 2007Article
- Oxytocin stimulates secretory processes in lactating rabbit mammary epithelial cells.The Journal of physiology · 2006Article
- Myoepithelial cells: their origin and function in breast morphogenesis and neoplasia.Journal of mammary gland biology and neoplasia · 2005Review
- Oxytocin receptor signaling in myoepithelial and cancer cells.Journal of mammary gland biology and neoplasia · 2005Review
- Improved radiotracing of oxytocin receptor-expressing tumours using the new [111In]-DOTA-Lys8-deamino-vasotocin analogue.British journal of cancer · 2003Article
- Estradiol and progesterone regulate oxytocin receptor binding and expression in human breast cancer cell lines.Endocrine · 2002Article
- Differentiation and cancer in the mammary gland: shedding light on an old dichotomy.Advances in cancer research · 1998Review
- Constitutive and ligand-induced nuclear localization of oxytocin receptor.Journal of cellular and molecular medicineArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent evidence indicates that oxytocin (OT), in addition to the induction of myometrial and myoepithelial cell contraction, can influence proliferation and differentiation in developing mammary glands and in breast cancer cells, hence the interest in detecting and locating OT receptors (OTRs). We produced rabbit antisera and a monoclonal antibody against a synthetic peptide corresponding to the carboxy terminus of the predicted OTR sequence. We tested their specificity in immunoblasts and immunocytochemical tests. All of the antibodies specifically stained myometrium (at term of pregnancy). In the human breast, OTRs were detected in myoepithelial cells along ducts of normal lobules and in sclerosing adenosis. Intraductal cells in benign hyperplastic lesions were also positive. OTRs were demonstrated in cases of primary and metastatic carcinomas of the breast. In the same tissues, OTR gene expression was shown by reverse transcriptase polymerase chain reaction procedures detecting the specific mRNA. These results suggest that the interaction between OT and its receptors might play a role in the origin and evolution of non-neoplastic lesions and carcinomas of the breast.
Indexed as
Identifiers
8669475PMC1861656W1780866292What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.