ArticleThe American journal of pathology1996
Hyaluronan distribution in the normal epithelium of esophagus, stomach, and colon and their cancers.
Article in The American journal of pathology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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Who cites it
38 citing papers in PubMed, 129 citations in OpenAlex.
- Hyaluronic Acid Decoration Facilitates CD44-Mediated Targeting and Alters Protein Corona Formation of Extracellular Vesicles.Journal of extracellular vesicles · 2026Article
- High prevalence of CD44 and its ligand low molecular weight hyaluronan in plasma of HNSCC patients: clinical significance.Molecular biology reports · 2024Article
- 'Two-faces' of hyaluronan, a dynamic barometer of disease progression in tumor microenvironment.Discover oncology · 2023Review
- Irradiation Alters the Expression of MUC1, CD44 and Hyaluronan in Oral Mucosal Epithelium.Biomedicines · 2022Article
- Detection of Glycosaminoglycans in Pancreatic Islets and Lymphoid Tissues.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Skin inflammation activates intestinal stromal fibroblasts and promotes colitis.The Journal of clinical investigation · 2021Article
- Prognostic implications of stromal hyaluronic acid protein expression in resected oropharyngeal and oral cavity cancers.The Korean journal of internal medicine · 2020Article
- The growth of a xenograft breast cancer tumor model with engineered hyaluronan-accumulating stroma is dependent on hyaluronan and independent of CD44.Oncotarget · 2019Article
- Extracellular Matrix in the Tumor Microenvironment and Its Impact on Cancer Therapy.Frontiers in molecular biosciences · 2019Review
- Article
- Fibromodulin deficiency reduces collagen structural network but not glycosaminoglycan content in a syngeneic model of colon carcinoma.PloS one · 2017Article
- Hyaluronic acid in digestive cancers.Journal of cancer research and clinical oncology · 2017Review
- The tumor microenvironment in esophageal cancer.Oncogene · 2016Review
- Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases.Science translational medicine · 2016Article
- Hyaluronan: More than just a wrinkle filler.Glycobiology · 2016Review
- Decreased expression of hyaluronan synthase 1 and 2 associates with poor prognosis in cutaneous melanoma.BMC cancer · 2016Article
- Hyaluronidases and hyaluronan synthases expression is inversely correlated with malignancy in lung/bronchial pre-neoplastic and neoplastic lesions, affecting prognosis.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2015Article
- Synergistic effect of targeting the epidermal growth factor receptor and hyaluronan synthesis in oesophageal squamous cell carcinoma cells.British journal of pharmacology · 2015Article
- Tissue hyaluronan expression, as reflected in the sputum of lung cancer patients, is an indicator of malignancy.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2015Article
- The detection of glycosaminoglycans in pancreatic islets and lymphoid tissues.Methods in molecular biology (Clifton, N.J.) · 2015Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The distribution of hyaluronan (HA) in normal gastrointestinal wall and in tumors originating from their epithelium was studied using a specific probe prepared from cartilage proteoglycan (bHABC, biotinylated hyaluronan binding complex). The normal stratified squamous epithelium of esophagus showed an intense HA staining in the basal and lower intermediate layers, whereas the simple epithelia in the stomach and large intestine were HA negative. Esophageal in situ carcinomas expressed HA also in the cell layers close to the luminal surface, in regions normally negative. Most of the invasive squamous cell carcinomas maintained their HA expression, but in very poorly differentiated types the tumor parenchyma was devoid of HA. In both gastric and colonic adenocarcinomas the tumor parenchyma showed no HA. The stromal tissue was intensely HA positive in all tumors. Cancer cells invading the intestinal smooth muscle were surrounded by copious amounts of HA, whereas the muscular layer was otherwise very poor in HA staining. These results show that relatively well differentiated carcinoma cells themselves retain the high or low HA expression pattern of their original epithelium, whereas tumors stimulate HA deposition in the surrounding stroma.
Indexed as
Identifiers
8669472PMC1861659W159594237What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.