ArticleThe American journal of pathology1996
Expression of neurofilaments and of a titin epitope in thymic epithelial tumors. Implications for the pathogenesis of myasthenia gravis.
Article in The American journal of pathology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed, 67 citations in OpenAlex.
- Pathogenesis of thymoma-associated myasthenia gravis: a narrative review.Mediastinum (Hong Kong, China) · 2025Review
- Thymic gene expression analysis reveals a potential link between HIF-1A and Th17/Treg imbalance in thymoma associated myasthenia gravis.Journal of neuroinflammation · 2024Article
- Muscle and Muscle-like Autoantigen Expression in Myasthenia Gravis Thymus: Possible Molecular Hint for Autosensitization.Biomedicines · 2023Article
- Narrative review of immunotherapy in thymic malignancies.Translational lung cancer research · 2021Review
- The Integrated Genomic Landscape of Thymic Epithelial Tumors.Cancer cell · 2018Article
- Thymus neuroendocrine tumors with CTNNB1 gene mutations, disarrayed ß-catenin expression, and dual intra-tumor Ki-67 labeling index compartmentalization challenge the concept of secondary high-grade neuroendocrine tumor: a paradigm shift.Virchows Archiv : an international journal of pathology · 2017Article
- Clinical features, pathogenesis, and treatment of myasthenia gravis: a supplement to the Guidelines of the German Neurological Society.Journal of neurology · 2016Review
- Antibodies against low-density lipoprotein receptor-related protein 4 induce myasthenia gravis.The Journal of clinical investigation · 2013Article
- CD24 on thymic APCs regulates negative selection of myelin antigen-specific T lymphocytes.European journal of immunology · 2012Article
- Three types of striational antibodies in myasthenia gravis.Autoimmune diseases · 2011Article
- The significance of titin antibodies in myasthenia gravis--correlation with thymoma and severity of myasthenia gravis.Journal of neurology · 2004Article
- Antibodies to ion channels in paraneoplastic disorders.Brain pathology (Zurich, Switzerland) · 1999Review
- A pathogenetic role for the thymoma in myasthenia gravis. Autosensitization of IL-4- producing T cell clones recognizing extracellular acetylcholine receptor epitopes presented by minority class II isotypes.The Journal of clinical investigation · 1998Article
- Human autoantibodies reveal titin as a chromosomal protein.The Journal of cell biology · 1998Article
- Epitopes expressed in myasthenia gravis (MG) thymomas are not recognized by patients' T cells or autoantibodies.Clinical and experimental immunology · 1998Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autoantibodies against both striated muscle proteins, particularly titin, and the acetylcholine receptor are a hallmark of thymoma-associated myasthenia gravis. However, the stimulus for these responses remains enigmatic as whole titin is not detectable in these tumors. This study reports that in thymomas with cortical differentiation many of the neoplastic epithelial cells expressed low and medium molecular weight neurofilaments detected with several antibodies (on selections and blots) and at the RNA level (by reverse transcriptase polymerase chain reaction). Moreover, higher molecular weight forms sharing at least one epitope with titin were detectable slightly less frequently, as were the more strongly phosphorylated epitopes. In stark contrast, in medullary and mixed thymomas, and especially in the normal thymus, immunoreactivity with anti-neurofilament antibodies was rare. This aberrant overexpression of a titin epitope by epithelial cells with antigen-presenting phenotype in an inappropriate cortical microenvironment suggests that they might autosensitize maturing T cells there and so initiate anti-titin autoimmunity in these patients.
Indexed as
Identifiers
8669470PMC1861646W2208179710What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.