ArticleThe American journal of pathology1996
Widespread neuronal expression of the presenilin-1 early-onset Alzheimer's disease gene in the murine brain.
Article in The American journal of pathology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 56 citations in OpenAlex.
- Calcium Signaling Regulated by Cellular Membrane Systems and Calcium Homeostasis Perturbed in Alzheimer's Disease.Frontiers in cell and developmental biology · 2022Review
- Molecular basis of etiological implications in Alzheimer's disease: focus on neuroinflammation.Molecular neurobiology · 2013Review
- Pathology associated with AAV mediated expression of beta amyloid or C100 in adult mouse hippocampus and cerebellum.PloS one · 2013Article
- Evidence that enzyme processivity mediates differential Aβ production by PS1 and PS2.Current Alzheimer research · 2013Article
- Aberrant detergent-insoluble excitatory amino acid transporter 2 accumulates in Alzheimer disease.Journal of neuropathology and experimental neurology · 2010Article
- Age-related vascular pathology in transgenic mice expressing presenilin 1-associated familial Alzheimer's disease mutations.The American journal of pathology · 2010Article
- Genetic studies in Alzheimer's disease.Dialogues in clinical neuroscience · 2003Article
- Adverse effect of a presenilin-1 mutation in microglia results in enhanced nitric oxide and inflammatory cytokine responses to immune challenge in the brain.Neuromolecular medicine · 2002Article
- Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice.The Journal of cell biology · 2000Article
- Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Expression of presenilin 1 mRNA in rat peripheral organs and brain.The Histochemical journal · 1999Article
- Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: evidence for novel species-specific properties of human presenilin-1.Molecular medicine (Cambridge, Mass.) · 1999Article
- Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Increased sensitivity to mitochondrial toxin-induced apoptosis in neural cells expressing mutant presenilin-1 is linked to perturbed calcium homeostasis and enhanced oxyradical production.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Calbindin D28k blocks the proapoptotic actions of mutant presenilin 1: reduced oxidative stress and preserved mitochondrial function.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Presenilin-1 is associated with Alzheimer's disease amyloid.The American journal of pathology · 1997Article
- Neuronal localization of presenilin-1 and association with amyloid plaques and neurofibrillary tangles in Alzheimer's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Presenilin-1-immunoreactive neurons are preserved in late-onset Alzheimer's disease.The American journal of pathology · 1997Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Mutations in the presenilin-1 (S182) gene have been genetically linked to early-onset Alzheimer's disease. To clarify the underlying molecular mechanism through which presenilin-1 is involved in the pathogenesis of this neurodegenerative disorder, the regional and cellular transcription profile of this gene was characterized in primary cells isolated from the murine brain by Northern blot hybridization using digoxigenin-labeled riboprobes. Our results indicate that presenilin-1 mRNA transcripts are widely distributed throughout the adult mouse brain. Furthermore, immunohistochemical labeling of hybridized sections indicates that expression was predominantly localized to neuronal cells. Neurons in the hippocampus and cerebral cortex, which are severely compromised in Alzheimer's disease, showed prominent expression of presenilin-1. In contrast, white matter areas and endothelial cells do not appear to express presenilin-1 to detectable levels. presenilin-1 transcripts, however, are also present less frequently in certain nonneuronal cell populations such as ependymal cells in the choroid plexus. Analysis of primary cells isolated from murine brain supported the results obtained by in situ hybridization and showed that cultured primary neurons and astrocytes express presenilin-1. Overall, it appears that the pattern of presenilin-1 gene expression parallels that previously described for the amyloid precursor protein.
Indexed as
Identifiers
8669467PMC1861636W1851679826What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.