ArticleThe American journal of pathology1996
Localization of human herpes-like virus type 8 in vascular endothelial cells and perivascular spindle-shaped cells of Kaposi's sarcoma lesions by in situ hybridization.
Article in The American journal of pathology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed, 103 citations in OpenAlex.
- Towards Better Understanding of KSHV Life Cycle: from Transcription and Posttranscriptional Regulations to Pathogenesis.Virologica Sinica · 2019Review
- Kaposi's Sarcoma-Associated Herpesvirus Nonstructural Membrane Protein pK15 Recruits the Class II Phosphatidylinositol 3-Kinase PI3K-C2α To Activate Productive Viral Replication.Journal of virology · 2018Article
- [Seroprevalence of human herpes virus-8 in HIV-positive patients at the General Hospital of Yaounde - Cameroon].The Pan African medical journal · 2015Article
- CXCR7 expression disrupts endothelial cell homeostasis and causes ligand-dependent invasion.Cell adhesion & migration · 2014Article
- Infection of the endothelium by members of the order Rickettsiales.Thrombosis and haemostasis · 2009Review
- Effects of chemotherapy in AIDS-associated non-Hodgkin's lymphoma on Kaposi's sarcoma herpesvirus DNA in blood.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2009Article
- Pre-micro RNA signatures delineate stages of endothelial cell transformation in Kaposi sarcoma.PLoS pathogens · 2009Article
- The viral etiology of AIDS-associated malignancies.Advances in pharmacology (San Diego, Calif.) · 2008Review
- Surface downregulation of major histocompatibility complex class I, PE-CAM, and ICAM-1 following de novo infection of endothelial cells with Kaposi's sarcoma-associated herpesvirus.Journal of virology · 2003Article
- Kaposi's sarcoma-associated herpesvirus-induced upregulation of the c-kit proto-oncogene, as identified by gene expression profiling, is essential for the transformation of endothelial cells.Journal of virology · 2002Article
- Spectrum of Kaposi's sarcoma-associated herpesvirus, or human herpesvirus 8, diseases.Clinical microbiology reviews · 2002Review
- Epidemiology and pathogenesis of Kaposi's sarcoma-associated herpesvirus.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2001Review
- Identification of a spliced gene from Kaposi's sarcoma-associated herpesvirus encoding a protein with similarities to latent membrane proteins 1 and 2A of Epstein-Barr virus.Journal of virology · 1999Article
- Long-term infection and transformation of dermal microvascular endothelial cells by human herpesvirus 8.Journal of virology · 1999Article
- High expression of HHV-8-encoded ORF73 protein in spindle-shaped cells of Kaposi's sarcoma.The American journal of pathology · 1999Article
- Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphoma.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Macrophages are the major reservoir of latent murine gammaherpesvirus 68 in peritoneal cells.Journal of virology · 1999Article
- Kinetics of Kaposi's sarcoma-associated herpesvirus gene expression.Journal of virology · 1999Article
- Complete sequence and genomic analysis of murine gammaherpesvirus 68.Journal of virology · 1997Article
- Summary of the II International Consensus Symposium on Combined Antiviral Therapy and implications for future therapies.Antiviral research · 1997Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
Abstract
Kaposi's sarcoma (KS) is a neoplasm that develops as multifocal lesions characterized by a histological picture that includes irregularly shaped vascular spaces surrounded by perivascular and interstitial spindle-shaped cells, extravasated erythrocytes, and an inflammatory mononuclear cell infiltrate. Recently, the DNA sequences of a novel human gamma-herpesvirus-like (HHV-8) agent have been detected by polymerase chain reaction in KS associated with acquired immune deficiency syndrome (AIDS-KS), classical KS, and African endemic KS. The present study was done to identify the specific cells within KS tumors that contain the viral DNA. Fourteen skin biopsy specimens, including three classical KSs, six AIDS-KSs, three normal skin specimens, and two common warts from healthy individuals, were examined by polymerase chain reaction for the presence of the HHV-8 DNA sequences. HHV-8 DNA were present in all nine KS specimens but not detectable in the five non-KS tissue samples. Using in situ hybridization, we found the HHV-8 DNA sequences to be predominantly localized to the nuclei of endothelial cells lining the vascular slits and some perivascular spindle-shaped cells, in two of three KS and four of six AIDS-KS tissue sections examined. The HHV-8-positive cells of KS specimens were concurrently shown to also be positive for factor-VIII-related antigen by immunohistochemical staining. The presence of the DNA of HHV-8 in the nuclei of KS cells further supports the possibility that this agent may play a role in the pathogenesis of this tumor.
Indexed as
Identifiers
8669460PMC1861629W2292695347What OpenQuestion holds
Registered trials
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