ArticleNucleic acids research1996
Transcriptional activation by Oct-3: evidence for a specific role of the POU-specific domain in mediating functional interaction with Oct-1.
Article in Nucleic acids research, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- The Role of E3s in Regulating Pluripotency of Embryonic Stem Cells and Induced Pluripotent Stem Cells.International journal of molecular sciences · 2021Review
- Phosphorylation of ThreonineStem cell reports · 2017Article
- A defined Oct4 level governs cell state transitions of pluripotency entry and differentiation into all embryonic lineages.Nature cell biology · 2013Article
- Probing transcription factor diffusion dynamics in the living mammalian embryo with photoactivatable fluorescence correlation spectroscopy.Nature communications · 2013Article
- Distinct functions of acj6 splice forms in odor receptor gene choice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Reversal of Xenopus Oct25 function by disruption of the POU domain structure.The Journal of biological chemistry · 2010Article
- The EWS-Oct-4 fusion gene encodes a transforming gene.The Biochemical journal · 2007Article
- Involvement of the ubiquitous Oct-1 transcription factor in hormonal induction of beta-casein gene expression.The Biochemical journal · 2007Article
- Use of altered-specificity binding Oct-4 suggests an absence of pluripotent cell-specific cofactor usage.Nucleic acids research · 2005Article
- Phenotypic complementation establishes requirements for specific POU domain and generic transactivation function of Oct-3/4 in embryonic stem cells.Molecular and cellular biology · 2002Article
- The specific activation of gadd45 following UVB radiation requires the POU family gene product N-oct3 in human melanoma cells.Oncogene · 2001Article
- Synergism with germ line transcription factor Oct-4: viral oncoproteins share the ability to mimic a stem cell-specific activity.Molecular and cellular biology · 1999Article
- Rex-1, a gene encoding a transcription factor expressed in the early embryo, is regulated via Oct-3/4 and Oct-6 binding to an octamer site and a novel protein, Rox-1, binding to an adjacent site.Molecular and cellular biology · 1998Article
- POU domain transcription factors in embryonic development.Molecular biology reports · 1997Review
- The carboxy-terminal transactivation domain of Oct-4 acquires cell specificity through the POU domain.Molecular and cellular biology · 1997Article
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2 authors.
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Abstract
Oct-3, a member of the POU family of transcription factors, is expressed in pluripotent cells of early mammalian embryos and in undifferentiated embryonal carcinoma cell lines. Using a variety of Oct-3 mutants, we have identified two different domains of Oct-3 which activate transcription in transfected mammalian cells. One of these domains, located in the C-terminal part of the protein, plays a major role in transcriptional activation when Oct-3 is bound to its cognate site, the octamer motif. An Oct-3 mutant containing a single amino acid substitution in the POU homeodomain is unable to bind the octamer target in vitro, yet is still able to activate transcription in an octamer-dependent manner. We provide evidence that transactivation by this mutant involves protein-protein interactions with the ubiquitous octamer binding factor Oct-1. This interaction requires the POU-specific domain of Oct-3 and allows recruitment of Oct-3 to the target promoter even in the absence of Oct-3 DNA binding.
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