ArticleNucleic acids research1996
Hdf1, a yeast Ku-protein homologue, is involved in illegitimate recombination, but not in homologous recombination.
Article in Nucleic acids research, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 54 citations in OpenAlex.
- Ku complex suppresses recombination in the absence of MRX activity during budding yeast meiosis.BMB reports · 2019Article
- Review
- Yeast recombination pathways triggered by topoisomerase II-mediated DNA breaks.Nucleic acids research · 2003Article
- Competition between the Rad50 complex and the Ku heterodimer reveals a role for Exo1 in processing double-strand breaks but not telomeres.Molecular and cellular biology · 2003Article
- Multiple pathways promote short-sequence recombination in Saccharomyces cerevisiae.Molecular and cellular biology · 2002Article
- NHEJ regulation by mating type is exercised through a novel protein, Lif2p, essential to the ligase IV pathway.Genes & development · 2001Article
- SIR functions are required for the toleration of an unrepaired double-strand break in a dispensable yeast chromosome.Molecular and cellular biology · 2001Article
- Article
- Repair of intermediate structures produced at DNA interstrand cross-links in Saccharomyces cerevisiae.Molecular and cellular biology · 2000Article
- Subtelomeric repeat amplification is associated with growth at elevated temperature in yku70 mutants of Saccharomyces cerevisiae.Genetics · 2000Article
- DNA damage-inducible and RAD52-independent repair of DNA double-strand breaks in Saccharomyces cerevisiae.Genetics · 2000Article
- Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex.Genes & development · 1999Article
- RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase.Genetics · 1999Article
- Distinct roles of two separable in vitro activities of yeast Mre11 in mitotic and meiotic recombination.The EMBO journal · 1998Article
- Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseases.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- The SbcCD nuclease of Escherichia coli is a structural maintenance of chromosomes (SMC) family protein that cleaves hairpin DNA.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Requirement for end-joining and checkpoint functions, but not RAD52-mediated recombination, after EcoRI endonuclease cleavage of Saccharomyces cerevisiae DNA.Molecular and cellular biology · 1998Article
- Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids.Nucleic acids research · 1998Review
- Radiation-induced chromosome aberrations in Saccharomyces cerevisiae: influence of DNA repair pathways.Genetics · 1998Article
- Nonhomologous end joining during restriction enzyme-mediated DNA integration in Saccharomyces cerevisiae.Molecular and cellular biology · 1998Article
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Hdf1 is the yeast homologue of the mammalian 70 kDa subunit of Ku-protein, which has DNA end-binding activity and is involved in DNA double-strand break repair and V(D)J recombination. To examine whether Hdf1 is involved in illegitimate recombination, we have measured the rate of deletion mutation caused by illegitimate recombination on a plasmid in an hdf1 disruptant. The hdf1 mutation reduced the rate of deletion formation by 20-fold, while it did not affect mitotic and meiotic homologous recombinations between two heteroalleles or homologous recombination between direct repeats. Hence Hdf1 participates in illegitimate recombination, but not in homologous recombination, in contrast to Rad52, Rad50, Mre11 and Xrs2, which are involved in both homologous and illegitimate recombination. The illegitimate recombination in the hdf1 disruptant took place between recombination sites that shared short regions of homology (1-4 bp), as was observed in the wild-type. Based on the DNA end-binding activity of Hdf1, we discuss models in which Hdf1 plays an important role in the late step of illegitimate recombination.
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