ArticleNucleic acids research1996
An essential domain in Saccharomyces cerevisiae U14 snoRNA is absent in vertebrates, but conserved in other yeasts.
Article in Nucleic acids research, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- RNase III cleavage sites spread across splice junctions enforce sequential snoRNA processing.EMBO reports · 2025Article
- The Efg1-Bud22 dimer associates with the U14 snoRNP contacting the 5' rRNA domain of an early 90S pre-ribosomal particle.Nucleic acids research · 2024Article
- snoRNPs: Functions in Ribosome Biogenesis.Biomolecules · 2020Review
- Knock-Down of a Novel snoRNA inBiomolecules · 2018Article
- The Transcriptome ofFrontiers in cellular and infection microbiology · 2016Article
- Conservation and divergence of transcriptional coregulations between box C/D snoRNA and ribosomal protein genes in Ascomycota.RNA (New York, N.Y.) · 2014Article
- Experimental identification and analysis of macronuclear non-coding RNAs from the ciliate Tetrahymena thermophila.Nucleic acids research · 2012Article
- Insights into corn genes derived from large-scale cDNA sequencing.Plant molecular biology · 2009Article
- Evolutionary patterns of non-coding RNAs.Theory in biosciences = Theorie in den Biowissenschaften · 2005Article
- The snoRNA box C/D motif directs nucleolar targeting and also couples snoRNA synthesis and localization.The EMBO journal · 1998Article
- Processing of a dicistronic small nucleolar RNA precursor by the RNA endonuclease Rnt1.The EMBO journal · 1998Article
- Small nucleolar RNAs and pre-rRNA processing in plants.The Plant cell · 1998Review
- The U14 snoRNA is required for 2'-O-methylation of the pre-18S rRNA in Xenopus oocytes.RNA (New York, N.Y.) · 1998Article
- The rRNA-processing function of the yeast U14 small nucleolar RNA can be rescued by a conserved RNA helicase-like protein.Molecular and cellular biology · 1997Article
- Article
- Small RNA database.Nucleic acids research · 1997Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
U14 is a small nucleolar RNA (snoRNA) required for early cleavages of eukaryotic precursor rRNA. The U14 RNA from Saccharomyces cerevisiae is distinguished from its vertebrate homologues by the presence of a stem-loop domain that is essential for function. This element, known as the Y-domain, is located in the U14 sequence between two universal sequences that base pair with 18S rRNA. Sequence data obtained for the U14 homologues from four additional phylogenetically distinct yeasts showed the Y-domain is not unique to S.cerevisiae. Comparison of the five Y-domain sequences revealed a common stem-loop structure with a conserved loop sequence that includes eight invariant nucleotides. Conservation of these features suggests that the Y-domain is a recognition signal for an essential interaction. Several plant U14 RNAs were found to contain similar structures, though with an unrelated consensus sequence in the loop portion. The U14 gene from the most distantly related yeast, Schizosaccharomyces pombe, was found to be active in S.cerevisiae, showing that Y-domain function is conserved and that U14 function can be provided by variants in which the essential elements are embedded in dissimilar flanking sequences. This last result suggests that U14 function may be determined solely by the essential elements.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.